ReviewStroke and vascular neurology2018
Patent foramen ovale and cryptogenic stroke: diagnosis and updates in secondary stroke prevention.
Review in Stroke and vascular neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- The relationship between anxiety and patent foramen ovale: a preliminary study.BMC psychology · 2026Observational
- Isolated Aphasia From a Left Parietotemporal Infarct Secondary to a Patent Foramen Ovale: A Case Report.Cureus · 2025Article
- Retrospective Comparison of Device Versus Suture for Patent Foramen Ovale Closure.Heart international · 2025Article
- A preserved transseptal puncture zone in a novel PFO occluder enables safe repeat left atrial interventions: preclinical validation in a porcine model.Frontiers in cardiovascular medicine · 2025Article
- Right Atrial Septal In Situ Microthrombus: A Potential Novel Cause of Patent Foramen Ovale-Associated Stroke.Journal of the American Heart Association · 2024Article
- Article
- Right-to-Left Shunt Evaluation in Cardiac Patent Foramen Ovale Using Bubble Contrast Transcranial Color-Coded Doppler: A Cryptogenic Stroke Case.Healthcare (Basel, Switzerland) · 2023Article
- Prevalence of Symptomatic Nonstenotic Carotid Disease Using Simultaneous Non-Contrast Angiography and Intraplaque Hemorrhage Imaging for MR Screen Protocol.Diagnostics (Basel, Switzerland) · 2022Article
- Patent foramen ovale: diagnostic evaluation and the role of device closure.Clinical medicine (London, England) · 2022Review
- A Review of the Role of Transthoracic and Transesophageal Echocardiography, Computed Tomography, and Magnetic Resonance Imaging in Cardioembolic Stroke.Medical science monitor : international medical journal of experimental and clinical research · 2022Review
- Evaluating Rates of Recurrent Ischemic Stroke Among Young Adults With Embolic Stroke of Undetermined Source: The Young ESUS Longitudinal Cohort Study.JAMA neurology · 2022Article
- Patent Foramen Ovale-A Not So Innocuous Septal Atrial Defect in Adults.Journal of cardiovascular development and disease · 2021Review
- Multidisciplinary assessment of patients with ischemic stroke, the structure of a stroke team, and first Egyptian experience in adults undergoing transcatheter PFO closure for PFO-related stroke.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2021Article
- Atrial septal defect closure in a young patient presenting with recurrent cryptogenic stroke: a case report.Journal of cardiothoracic surgery · 2020Article
- Paradoxical embolism through PFO leading to stroke in a gunshot victim with IVC injury.Journal of surgical case reports · 2018Article
- The Relationship Between the Triglyceride-Glucose Index and Cryptogenic Stroke in Patients with Patent Foramen Ovale.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
- Patent foramen ovale with cryptogenic stroke: A case report.Medicine internationalArticle
- Bubble-test for detection of a patent foramen ovale in young to middle-aged ischemic stroke patients.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The patent foramen ovale (PFO), given its high prevalence in the general population and especially in patients with cryptogenic stroke, has long generated investigation and debate on its propensity for stroke by paradoxical embolism and its management for stroke prevention. The pendulum has swung for percutaneous PFO closure for secondary stroke prevention in cryptogenic stroke. Based on a review of current evidence, the benefit from PFO closure relies on careful patient selection: those under the age of 60 years with few to no vascular risk factors and embolic-appearing stroke deemed cryptogenic after thorough evaluation. As these data look towards influencing guideline statements and device approvals in the future, patient selection remains the crucial ingredient for clinical decision making and future trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.