ReviewStroke and vascular neurology2018
Cardioembolic stroke: everything has changed.
Review in Stroke and vascular neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- [Prognostic analysis of anticoagulation therapy in elderly patients with cardioembolic stroke].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026Article
- Functional and reperfusion outcomes after mechanical thrombectomy at high altitude: a 32-patient series from Quito, Ecuador.Neuroradiology · 2026Article
- Molecular Pathophysiology of Ischemic Stroke and Mesenchymal Stem Cell Based Therapeutic Strategies for Neural Tissue Regeneration: A Pre-clinical and Clinical Perspective.Stem cell reviews and reports · 2026Review
- Association Between Environmental Chemicals Phthalates and Stroke Among the US Adults: A Cross-Sectional Study.Cardiovascular toxicology · 2026Article
- Characteristics and outcomes of previously known versus newly detected atrial fibrillation after ischemic stroke.BMC cardiovascular disorders · 2025Article
- Review
- Management of cerebral amyloid angiopathy and atrial fibrillation: We are still far from precision medicine.World journal of cardiology · 2024Review
- Association of Metallic and Nonmetallic Elements with Fibrin Clot Properties and Ischemic Stroke.Life (Basel, Switzerland) · 2024Article
- Homocysteine thiolactone and other sulfur-containing amino acid metabolites are associated with fibrin clot properties and the risk of ischemic stroke.Scientific reports · 2024Article
- A Simple Score for Predicting Paroxysmal Atrial Fibrillation in Patients with Embolic Stroke of Undetermined Source in a Tunisian Cohort Study.Current neurovascular research · 2024Article
- Prolonged Secondary Stroke Prevention with Edoxaban: A Long-Term Follow-Up of the SATES Study.Brain sciences · 2023Article
- Article
- Three-dimensional simulations of embolic stroke and an equation for sizing emboli from imaging.Scientific reports · 2023Article
- Development and refinement of diagnostic and therapeutic strategies for managing patients with cardiogenic stroke: An arduous journey.World journal of clinical cases · 2023Review
- Impact of Anticoagulants in Reducing Mortality and Disability in Cardioembolic Stroke Patients.Medicina (Kaunas, Lithuania) · 2022Article
- Plasma Total Homocysteine Level Is Related to Unfavorable Outcomes in Ischemic Stroke With Atrial Fibrillation.Journal of the American Heart Association · 2022Article
- Ischemic Stroke of Suspected Cardioembolic Origin Despite Anticoagulation: Does Thrombus Analysis Help to Clarify Etiology?Frontiers in neurology · 2022Article
- Applying Machine Learning to Carotid Sonographic Features for Recurrent Stroke in Patients With Acute Stroke.Frontiers in cardiovascular medicine · 2022Article
- The role of leukocytes in acute ischemic stroke-related thrombosis: a notable but neglected topic.Cellular and molecular life sciences : CMLS · 2021Review
- Management of asymptomatic carotid stenosis.Annals of translational medicine · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Historically, because of the difficulty of using warfarin safely and effectively, many patients with cardioembolic stroke who should have been anticoagulated were instead given ineffective antiplatelet therapy (or no antithrombotic therapy). With the arrival of new oral anticoagulants that are not significantly more likely than aspirin to cause severe haemorrhage, everything has changed. Because antiplatelet agents are much less effective in preventing cardioembolic stroke, it is now more prudent to anticoagulate patients in whom cardioembolic stroke is strongly suspected. Recent advances include the recognition that intermittent atrial fibrillation is better detected with more prolonged monitoring of the cardiac rhythm, and that percutaneous closure of patent foramen ovale (PFO) may reduce the risk of stroke. However, because in most patients with stroke and PFO the PFO is incidental, this should be reserved for patients in whom paradoxical embolism is likely. A high shunt grade on transcranial Doppler saline studies, and clinical clues to paradoxical embolism, can help in appropriate selection of patients for percutaneous closure. For patients with atrial fibrillation who cannot be anticoagulated, ablation of the left atrial appendage is an emerging option. It is also increasingly recognised that high levels of homocysteine, often due to undiagnosed metabolic deficiency of vitamin B
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.