Evidence map›Paper›PMID 30022489›Full record

ArticleJournal of anatomy2018

Intraganglionic macrophages: a new population of cells in the enteric ganglia.

David Dora, Emily Arciero, Ryo Hotta, Csilla Barad, Sukhada Bhave, Tamas Kovacs, Adam Balic, Allan M Goldstein, Nandor Nagy

Open access · bronzeAbstract read
In one paragraph

Article in Journal of anatomy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. The enteric nervous system.Physiological reviews · 2023
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Journal of Anatomy January 2020.Journal of anatomy · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

David DoraDepartment of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Emily ArcieroDepartment of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ryo HottaDepartment of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Csilla BaradDepartment of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Sukhada BhaveDepartment of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Tamas KovacsDepartment of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Adam BalicThe Roslin Institute and Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Edinburgh, UK.
Allan M GoldsteinDepartment of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Nandor NagyDepartment of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.ORCID 0000-0002-6223-5214
Harvard University · USSemmelweis University · HURoslin Institute · GB

Funding

Developmentally Informed Approach to Cell-based Therapy for Enteric NeuropathiesR01DK103785 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI GOLDSTEIN, ALLAN M · 2015 to 2019
$1.9M
Biotechnology and Biological Sciences Research Council BBS/E/D/20320000NIDDK NIH HHS R01 DK103785NIH HHS R01DK103785
6 · The paper itself

Abstract

The enteric nervous system shares embryological, morphological, neurochemical, and functional features with the central nervous system. In addition to neurons and glia, the CNS includes a third component, microglia, which are functionally and immunophenotypically similar to macrophages, but a similar cell type has not previously been identified in enteric ganglia. In this study we identify a population of macrophages in the enteric ganglia, intermingling with the neurons and glia. These intraganglionic macrophages (IMs) are highly ramified and express the hematopoietic marker CD45, major histocompatibility complex (MHC) class II antigen, and chB6, a marker specific for B cells and microglia in avians. These IMs do not express antigens typically associated with T cells or dendritic cells. The CD45

Indexed as

AnimalsChick EmbryoEnteric Nervous SystemGangliaMacrophagesNeuroimmunomodulationCSF1RCX3CR1enteric gangliaenteric nervous systemmacrophagesmicroglia

Identifiers

PMID30022489
PMCPMC6131971
OpenAlexW2883037857

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.