ArticleBiological trace element research2019
Iron Deficiency Reduces Synapse Formation in the Drosophila Clock Circuit.
Article in Biological trace element research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Rescuing anxiety by targeting the neuronal-astrocytic iron signaling axis in male mice.Signal transduction and targeted therapy · 2026Article
- Iron Homeostasis and Reproduction: Unveiling the Microbiome-Gut-Brain Axis Connection in the MosquitoCells · 2026Article
- Rapamycin and Post-Deficiency Dietary Recovery Reshape Antioxidant Response and Survival in Offspring of Iron-Deficient Mothers.Biological trace element research · 2025Article
- Dietary Zinc Limitation Dictates Lifespan and Reproduction Trade-Offs of Drosophila Mothers.Aging cell · 2025Article
- Brain Iron Homeostasis and Mental Disorders.Antioxidants (Basel, Switzerland) · 2023Review
- The impact of iron and heme availability on the healthy human gut microbiome in vivo and in vitro.Cell chemical biology · 2023Article
- Exploring the causes of augmentation in restless legs syndrome.Frontiers in neurology · 2023Review
- Current understanding of metal ions in the pathogenesis of Alzheimer's disease.Translational neurodegeneration · 2020Review
- Multilevel Impacts of Iron in the Brain: The Cross Talk between Neurophysiological Mechanisms, Cognition, and Social Behavior.Pharmaceuticals (Basel, Switzerland) · 2019Review
- Impact of Autophagy and Aging on Iron Load and Ferritin inFrontiers in cell and developmental biology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Iron serves as a critical cofactor for proteins involved in a host of biological processes. In most animals, dietary iron is absorbed in enterocytes and then disseminated for use in other tissues in the body. The brain is particularly dependent on iron. Altered iron status correlates with disorders ranging from cognitive dysfunction to disruptions in circadian activity. The exact role iron plays in producing these neurological defects, however, remains unclear. Invertebrates provide an attractive model to study the effects of iron on neuronal development since many of the genes involved in iron metabolism are conserved, and the organisms are amenable to genetic and cytological techniques. We have examined synapse growth specifically under conditions of iron deficiency in the Drosophila circadian clock circuit. We show that projections of the small ventrolateral clock neurons to the protocerebrum of the adult Drosophila brain are significantly reduced upon chelation of iron from the diet. This growth defect persists even when iron is restored to the diet. Genetic neuronal knockdown of ferritin 1 or ferritin 2, critical components of iron storage and transport, does not affect synapse growth in these cells. Together, these data indicate that dietary iron is necessary for central brain synapse formation in the fly and further validate the use of this model to study the function of iron homeostasis on brain development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.