Evidence map›Paper›PMID 30022375›Full record

ReviewClinical and experimental medicine2018

Dipeptidyl peptidase-4(DPP-4) inhibitors: promising new agents for autoimmune diabetes.

Xia Wang, Peilin Zheng, Gan Huang, Lin Yang, Zhiguang Zhou

Open access · hybridAbstract readReview
PubMed Publisher
In one paragraph

Review in Clinical and experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 44 citations in OpenAlex.

  1. Pharmacologic DPP-4 inhibition promotes CD8bioRxiv : the preprint server for biology · 2026
    Article
  2. Observational
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Research on ACEI of Low-Molecular-Weight Peptides fromMolecules (Basel, Switzerland) · 2022
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Drug Delivery System in the Treatment of Diabetes Mellitus.Frontiers in bioengineering and biotechnology · 2020
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Xia WangDepartment of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Peilin ZhengDepartment of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Gan HuangDepartment of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Lin YangDepartment of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhiguang ZhouDepartment of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. zhouzhiguang@csu.edu.cn.ORCID http://orcid.org/0000-0002-0374-1838
Central South University · CN

Funding

the National Key R&D Program of China 2016YFC1305000the National Key R&D Program of China 2016YFC1305001the National Natural Science Foundation of China 81070627the National Natural Science Foundation of China 81170725the National Natural Science Foundation of China 8146168031the National Natural Science Foundation of China 81500600the National Science and Technology Infrastructure Program 2015BAI12B13
6 · The paper itself

Abstract

Dipeptidyl peptidase-4 (DPP-4) inhibitors constitute a novel class of anti-diabetic agents confirmed to improve glycemic control and preserve β-cell function in type 2 diabetes. Three major large-scale studies, EXAMINE, SAVOR-TIMI 53, and TECOS, have confirmed the cardiovascular safety profile of DPP-4 inhibitors. Based on these results, DPP-4 inhibitors have gained widespread use in type 2 diabetes treatment. It is currently unknown, however, whether DPP-4 inhibitors have similar therapeutic efficacy against autoimmune diabetes. Several in vitro and in vivo studies have addressed this issue, but the results remain controversial. In this review, we summarize experimental findings and preliminary clinical trial results, and identify potentially effective immune modulation targets of DPP-4 inhibitors for autoimmune diabetes.

Indexed as

AnimalsClinical Trials as TopicCytokinesDiabetes Mellitus, Type 1Dipeptidyl-Peptidase IV InhibitorsHumansImmunologic FactorsImmunomodulationT-Lymphocyte SubsetsCytokinesDipeptidyl-Peptidase IV InhibitorsImmunologic FactorsDPP-4 inhibitorIncretinLatent autoimmune diabetes in adultsType 1 diabetes

Identifiers

PMID30022375
OpenAlexW2884339835

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.