Evidence map›Paper›PMID 30022362›Full record

Trial reportEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2018

The comparison of single-dose preemptive intravenous ibuprofen and paracetamol on postoperative pain scores and opioid consumption after open septorhinoplasty: a randomized controlled study.

Erkan Cem Çelik, Duygu Kara, Ersen Koc, Ahmet Murat Yayik

Registry-linked trialAbstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06478758 (Ibuprofen Use on Post-operative Pain Following Cholecystectomy), which is not on this map. Cited by 12 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 4 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06478758 phase4completednot on this mapstarted 2024, after this paper: background citation

Ibuprofen Use on Post-operative Pain Following Cholecystectomy

TypeinterventionalSponsorGiresun UniversityRan2024 to 2024Enrolled71ConditionsAcute Post-operative PainArmsIbuprofen 400 mg, Acetaminophen 100 MG/ML
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 4 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pain management following septorhinoplasty surgery: evidence from a systematic review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Erkan Cem ÇelikDepartment of Anesthesiology and Reanimation, Erzurum Regional Training and Research Hospital, Erzurum, Turkey. drerkancem@yahoo.com.
Duygu KaraDepartment of Anesthesiology and Reanimation, Erzurum Regional Training and Research Hospital, Erzurum, Turkey.
Ersen KocOtorhinolaryngology Department, Palandoken State Hospital, Erzurum, Turkey.
Ahmet Murat YayikDepartment of Anesthesiology and Reanimation, Erzurum Regional Training and Research Hospital, Erzurum, Turkey.
Erzurum Regional Training and Research Hospital · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSeptorhinoplasty is performed in combination with septoplasty and rhinoplasty operations and is characterized by severe postoperative pain. The aim of this study is to evaluate preemptive effects of intravenous (IV) ibuprofen and IV paracetamol on opioid consumption and pain scores after open septorhinoplasty.

methodsThe study included 150 patients who had undergone elective open septorhinoplasty. Patients were randomly assigned into three groups; Group Control (Group C, n = 50) received 100 ml saline solution, Group Paracetamol (Group P, n = 50) received 1000 mg IV paracetamol in 100 ml solution, and Group Ibuprofen (Group I, n = 50) received 800 mg IV ibuprofen in 100 ml saline before surgery. Postoperative analgesia was achieved by opioid administration via patient-controlled analgesia. Visual analog scores (VASs), postoperative opioid consumption, additional analgesic requirements, and side effects were recorded.

resultsCompared with Group C, VASs in Group P and Group I were statistically lower at all time points (p < 0.05). VAS was lower in Group I than in Group P at postoperative, 1st and 6th hours (p < 0.05). Opioid consumption in Group C was highest in all groups at all time periods (p < 0.05). At the 0-6 and 6-12 time intervals, total opioid consumption was significantly lower in Group I compared to Group P (p < 0.05). Total opioid consumption was highest in Group C (p < 0.05).

conclusionsThis study has indicated that ibuprofen has more analgesic effect than paracetamol during first 12 h, but there is a non-inferiority between ibuprofen and paracetamol after first 12 h.

Indexed as

AcetaminophenAdministration, IntravenousAdultAnalgesia, Patient-ControlledAnalgesicsAnalgesics, OpioidDose-Response Relationship, DrugFemaleHumansIbuprofenMaleMiddle AgedNasal SeptumPain MeasurementPostoperative PainRhinoplastyAcetaminophenAnalgesicsAnalgesics, OpioidIbuprofenAnalgesiaAnesthesiaIbuprofenParacetamolSeptorhinoplasty

Identifiers

PMID30022362
OpenAlexW2884326030

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.