Evidence map›Paper›PMID 30022340›Full record

ArticleJournal of the American Society for Mass Spectrometry2018

Reference Parameters for Protein Hydrogen Exchange Rates.

David Nguyen, Leland Mayne, Michael C Phillips, S Walter Englander

Abstract read
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Intrinsic Hydrogen-Deuterium Exchange Rates in HThe journal of physical chemistry. B · 2026
    Article
  8. Article
  9. Histone Variant H2A.Z Enhances Histone and Nucleosome Dynamics.Molecular & cellular proteomics : MCP · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. The structural basis of cold sensitivity.bioRxiv : the preprint server for biology · 2025
    Article
  16. Article
  17. Crowding-induced stabilization and destabilization in a single protein.Protein science : a publication of the Protein Society · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

David NguyenJohnson Research Foundation, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. nguyend2@pennmedicine.upenn.edu.
Leland MayneJohnson Research Foundation, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Michael C PhillipsChildren's Hospital of Philadelphia, Philadelphia, PA, USA.
S Walter EnglanderJohnson Research Foundation, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Funding

Protein structure and function by hydrogen exchange mass spectrometry analysisR01GM031847 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI ENGLANDER, S. WALTER · 1985 to 2017
$6.3M
National Science Foundation MCB1020649NIGMS NIH HHS GM031846NIGMS NIH HHS R01 GM031847
6 · The paper itself

Abstract

The analysis of many hydrogen exchange (HX) experiments depends on knowledge of exchange rates expected for the unstructured protein under the same conditions. We present here some minor adjustments to previously calibrated values and a stringent test of their accuracy. Graphical Abstract ᅟ.

Indexed as

DeuteriumDeuterium Exchange MeasurementMass SpectrometryProteinsDeuteriumProteinsHDXHX MSHydrogen exchange

Identifiers

PMID30022340
PMCPMC6087487

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.