Evidence map›Paper›PMID 30022328›Full record

ArticleBreast cancer research and treatment2018

Onco-metabolism: defining the prognostic significance of obesity and diabetes in women with brain metastases from breast cancer.

Neal S McCall, Brittany A Simone, Minesh Mehta, Tingting Zhan, Kevin Ko, Kamila Nowak-Choi, Annaisabel Rese, Chantel Venkataraman, David W Andrews, Pramila R Anne' and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Hyperglycemia is associated with poor survival in patients with brain metastases treated with radiotherapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025
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  13. Targeting the Tumor Microenvironment in Radiation Oncology: Proceedings from the 2018 ASTRO-AACR Research Workshop.Clinical cancer research : an official journal of the American Association for Cancer Research · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Neal S McCallDepartment of Radiation Oncology, Sidney Kimmel Medical College at Thomas Jefferson University, Sidney Kimmel Cancer Center, Bodine Center, Suite G-301, 111 South 11th Street, Philadelphia, PA, 19107, USA.
Brittany A SimoneDepartment of Radiation Oncology, Sidney Kimmel Medical College at Thomas Jefferson University, Sidney Kimmel Cancer Center, Bodine Center, Suite G-301, 111 South 11th Street, Philadelphia, PA, 19107, USA.
Minesh MehtaDepartment of Radiation Oncology, Miami Cancer Institute at Baptist Health South Florida, Miami, FL, USA.
Tingting ZhanDivision of Biostatistics, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.
Kevin KoDepartment of Radiation Oncology, Sidney Kimmel Medical College at Thomas Jefferson University, Sidney Kimmel Cancer Center, Bodine Center, Suite G-301, 111 South 11th Street, Philadelphia, PA, 19107, USA.
Kamila Nowak-ChoiMedStar Franklin Square Medical Center, Rosedale, MD, USA.
Annaisabel ReseUniversity of Naples Federico II, Naples, Italy.
Chantel VenkataramanDepartment of Radiation Oncology, Sidney Kimmel Medical College at Thomas Jefferson University, Sidney Kimmel Cancer Center, Bodine Center, Suite G-301, 111 South 11th Street, Philadelphia, PA, 19107, USA.
David W AndrewsDepartment of Radiation Oncology, Sidney Kimmel Medical College at Thomas Jefferson University, Sidney Kimmel Cancer Center, Bodine Center, Suite G-301, 111 South 11th Street, Philadelphia, PA, 19107, USA.
Pramila R Anne'Department of Radiation Oncology, Sidney Kimmel Medical College at Thomas Jefferson University, Sidney Kimmel Cancer Center, Bodine Center, Suite G-301, 111 South 11th Street, Philadelphia, PA, 19107, USA.
Adam P DickerDepartment of Radiation Oncology, Sidney Kimmel Medical College at Thomas Jefferson University, Sidney Kimmel Cancer Center, Bodine Center, Suite G-301, 111 South 11th Street, Philadelphia, PA, 19107, USA.
Wenyin ShiDepartment of Radiation Oncology, Sidney Kimmel Medical College at Thomas Jefferson University, Sidney Kimmel Cancer Center, Bodine Center, Suite G-301, 111 South 11th Street, Philadelphia, PA, 19107, USA.
Nicole L SimoneDepartment of Radiation Oncology, Sidney Kimmel Medical College at Thomas Jefferson University, Sidney Kimmel Cancer Center, Bodine Center, Suite G-301, 111 South 11th Street, Philadelphia, PA, 19107, USA. Nicole.Simone@jefferson.edu.

Funding

X-Ray Crystallography and Macromolecular CharacterizationP30CA056036 · NCI · THOMAS JEFFERSON UNIVERSITY · PI DANIEL P SILVER · 1995 to 2026
$94.8M
Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI STEPHEN W BYERS · 1990 to 2026
$71.5M
Diet Modification to Augment Radiation for Breast Cancer Brain MetastasesR01CA227479 · NCI · THOMAS JEFFERSON UNIVERSITY · PI SIMONE, NICOLE L · 2018 to 2022
$2.0M
NCI NIH HHS P30 CA056036NCI NIH HHS R01 CA227479
6 · The paper itself

Abstract

purposeMetabolic dysregulation has been implicated as a molecular driver of breast cancer in preclinical studies, especially with respect to metastases. We hypothesized that abnormalities in patient metabolism, such as obesity and diabetes, may drive outcomes in breast cancer patients with brain metastases.

methodsWe retrospectively identified 84 consecutive patients with brain metastases from breast cancer treated with intracranial radiation therapy. Radiation was delivered as whole-brain radiation to a median dose of 3000 cGy or stereotactic radiosurgery to a median dose of 2100 cGy. Kaplan Meier curves were generated for overall survival (OS) data and Mantel-Cox regression was performed to detect differences in groups.

resultsAt analysis, 81 survival events had occurred and the median OS for the entire cohort was 21.7 months. Despite similar modified graded prognostic assessments, resection rates, and receptor status, BMI ≥ 25 kg/m

conclusionsElevated BMI or diabetes may negatively impact both overall survival and local control in patients with brain metastases from breast cancer, highlighting the importance of the translational development of therapeutic metabolic interventions. Given its prognostic significance, BMI should be used as a stratification in future clinical trial design in this patient population.

Indexed as

AdultAgedAged, 80 and overBrain NeoplasmsBreast NeoplasmsDiabetes MellitusFemaleHumansMiddle AgedObesityPrognosisRadiosurgeryTreatment OutcomeBrain metastasesBreast cancerDiabetesObesityRadiationRadiosurgery

Identifiers

PMID30022328
PMCPMC6558990

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.