Evidence map›Paper›PMID 30022292›Full record

ArticleParasitology research2018

Genetic variant strains of Leishmania (Viannia) braziliensis exhibit distinct biological behaviors.

Felipe Dutra Rêgo, Ana Cristina Vianna Mariano da Rocha Lima, Agnes Antônia Sampaio Pereira, Patrícia Flávia Quaresma, Marcelo Antônio Pascoal-Xavier, Jeffrey Jon Shaw, Célia Maria Ferreira Gontijo

Abstract read
PubMed Publisher
In one paragraph

Article in Parasitology research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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  5. Characterization of Differentially Abundant Proteins AmongFrontiers in cellular and infection microbiology · 2022
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  6. Novel Insights IntoFrontiers in cellular and infection microbiology · 2022
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  9. A New Target Organ ofFrontiers in cellular and infection microbiology · 2021
    Article
  10. Genomic Diversification, Structural Plasticity, and Hybridization inFrontiers in cellular and infection microbiology · 2020
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Felipe Dutra RêgoGrupo de Estudos em Leishmanioses, Instituto René Rachou, Fundação Oswaldo Cruz, Av. Augusto de Lima, 1715 Barro Preto, Belo Horizonte, Minas Gerais, 30190-002, Brazil. felipedutra04@hotmail.com.ORCID http://orcid.org/0000-0002-2799-8267
Ana Cristina Vianna Mariano da Rocha LimaGrupo de Estudos em Leishmanioses, Instituto René Rachou, Fundação Oswaldo Cruz, Av. Augusto de Lima, 1715 Barro Preto, Belo Horizonte, Minas Gerais, 30190-002, Brazil.
Agnes Antônia Sampaio PereiraGrupo de Estudos em Leishmanioses, Instituto René Rachou, Fundação Oswaldo Cruz, Av. Augusto de Lima, 1715 Barro Preto, Belo Horizonte, Minas Gerais, 30190-002, Brazil.
Patrícia Flávia QuaresmaGrupo de Estudos em Leishmanioses, Instituto René Rachou, Fundação Oswaldo Cruz, Av. Augusto de Lima, 1715 Barro Preto, Belo Horizonte, Minas Gerais, 30190-002, Brazil.
Marcelo Antônio Pascoal-XavierPesquisa Clínica e Políticas Públicas em Doenças Infecciosas e Parasitárias, Instituto René Rachou, Fundação Oswaldo Cruz, Av. Augusto de Lima, 1715 Barro Preto, Belo Horizonte, Minas Gerais, 30190-002, Brazil.
Jeffrey Jon ShawDepartamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Professor Lineu Prestes 1374, São Paulo, 05508-00, Brazil.
Célia Maria Ferreira GontijoGrupo de Estudos em Leishmanioses, Instituto René Rachou, Fundação Oswaldo Cruz, Av. Augusto de Lima, 1715 Barro Preto, Belo Horizonte, Minas Gerais, 30190-002, Brazil.
Fundação Oswaldo Cruz · BRUniversidade de São Paulo · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 479408/2010-6European Community LeishEpiNetSA 015407Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-00289-10
6 · The paper itself

Abstract

A variety of clinical forms of American cutaneous leishmaniasis (ACL) caused by Leishmania braziliensis, as well as differing immune responses of patients, have been reported for an ACL focus in the state of Minas Gerais, Brazil. In addition, two genetic profiles of L. braziliensis have been described, of which one variant profile (hsp70-variant) has been associated with atypical lesions. We investigated the biological behavior of genetic variant strains of L. braziliensis isolated from patients with different clinical manifestations of ACL. Experimental infections were performed with golden hamsters for five L. braziliensis strains in standardized doses of 1 × 10

Indexed as

AdultAnimalsBrazilCricetinaeGenetic VariationHSP70 Heat-Shock ProteinsHumansLeishmania braziliensisLeishmaniasis, CutaneousMaleMesocricetusSkinHSP70 Heat-Shock ProteinsBiological behaviorCutaneous leishmaniasisGenetic variantLeishmania braziliensis

Identifiers

PMID30022292
OpenAlexW2883486266

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.