ArticleEuropean journal of pediatrics2018
Outcome of routine cerebrospinal fluid screening for enterovirus and human parechovirus infection among infants with sepsis-like illness or meningitis in Cornwall, UK.
Article in European journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Quantitative and molecular adjudication of BioFire FilmArray and QIAstat-Dx discordance in meningitis/encephalitis diagnostics.Microbiology spectrum · 2026Article
- A post-implementation evaluation of BioFire FilmArray Meningitis/Encephalitis panel for pathogen detection in cerebrospinal fluid with a special focus on clinical significance of HHV-6.Microbiology spectrum · 2026Observational
- Clinical Impact of Cerebrospinal Fluid Multiplex Polymerase Chain Reaction (PCR) Testing in Children with Suspected Central Nervous System Infection.Medeniyet medical journal · 2025Article
- Enterovirus Meningitis.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Outbreak of Meningitis in Iraq in 2023.Global pediatric health · 2024Article
- Human parechovirus meningitis in children: state of the art.Italian journal of pediatrics · 2023Review
- Epidemiological characterization of viral etiological agents of the central nervous system infections among hospitalized patients in Egypt between 2016 and 2019.Virology journal · 2023Article
- Prospective, Cross-Sectional Study Finds No Common Viruses in Cerebrospinal Fluid of Children with Pseudotumor Cerebri.Brain sciences · 2023Article
- Detection of enterovirus in cerebrospinal fluids without pleocytosis in febrile infants under 3 months old reduces antibiotherapy duration.Frontiers in pediatrics · 2023Article
- Turnaround times for molecular testing of pediatric viral cerebrospinal fluid samples in United Kingdom laboratories.World journal of clinical pediatrics · 2022Article
- Genetic Variations in Human Parechovirus Type 3 in Infants with Central Nervous System Infection.Virologica Sinica · 2021Article
- The yield of CSF molecular testing in febrile neonates.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Review
- Year-Round, Routine Testing of Multiple Body Site Specimens for Human Parechovirus in Young Febrile Infants.The Journal of pediatrics · 2021Article
- Neurodevelopmental Outcomes of Infants Younger Than 90 Days Old Following Enterovirus and Parechovirus Infections of the Central Nervous System.Frontiers in pediatrics · 2021Article
- Etiology, Clinical Presentation and Incidence of Infectious Meningitis and Encephalitis in Polish Children.Journal of clinical medicine · 2020Article
- Impact of rapid enterovirus polymerase chain reaction testing on management of febrile young infants < 90 days of age with aseptic meningitis.BMC pediatrics · 2020Observational
- Human parechovirus meningitis and gross-motor neurodevelopment in young children.European journal of pediatrics · 2019Article
- TIPICO IX: report of the 9Human vaccines & immunotherapeutics · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Enteroviruses (EV) and human parechoviruses (HPeV) are known and emerging cause of sepsis-like illnesses in infants; however, testing is not yet routine. We retrospectively evaluated the number of diagnosed EV/HPeV infections in children under the age of 5 years who presented with sepsis-like illness or meningitis in Cornwall, UK, before and after routine implementation of viral screening of cerebrospinal fluid samples. During the 4-year period prior to routine testing, we identified 20 cases of EV meningitis and no cases of HPeV. In the year after introduction of routine screening, 27 cases of EV and 14 cases of HPeV were identified in 1 year. The majority of EV/HPeV infections occurred among children under 3 months old between May and August. Clinical and laboratory characteristics of EV and HPeV infections were mostly indistinguishable. We found that CSF pleocytosis and biochemistry-based testing strategy could miss 48.1 and 78.5% of EV and HPeV cases, respectively. With routine viral screening, the mean length of hospital stay (3.8 vs 5.9 days, P < 0.001) and antibiotic days (2.8 vs 4.7 days, P < 0.001) were significantly reduced in EV/HPeV-positive cases compared to a similar cohort without any detectable microbial aetiology.
conclusionRoutine EV and HPeV testing of CSF samples in children has the potential to reduce length of stay and antibiotic use. What is Known: • EV and HPeV are frequent cause of meningitis and sepsis-like illness among young children. • There is increasing evidence supporting routine EV and HPeV testing of paediatric CSF. What is New: • Outcome of routine EV and HPeV testing in Cornwall, UK. • The value of testing all paediatric CSF without any screening criteria. • A rapid diagnosis of EV/HPeV can significantly reduce length of hospital stay and unnecessary antibiotics.
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