Evidence map›Paper›PMID 30022253›Full record

Trial reportOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2018

VITamin D and OmegA-3 TriaL (VITAL) bone health ancillary study: clinical factors associated with trabecular bone score in women and men.

A L Goldman, C M Donlon, N R Cook, J E Manson, J E Buring, T Copeland, C Y Yu, M S LeBoff

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01747447 nacompletednot on this map

VITamin D and OmegA-3 TriaL: Effects on Bone Structure and Architecture

TypeinterventionalSponsorBrigham and Women's HospitalRan2012 to 2023Enrolled771ConditionsBone Density, Body Composition, Bone HealthArmsVitamin D3 placebo, Fish oil placebo, omega-3 fatty acids (fish oil), Vitamin D3
NCT04573946 naactive not recruitingnot on this mapstarted 2019, after this paper: background citation

VITamin D and OmegA-3 TriaL: Interrelationship of Vitamin D and Vitamin K on Bone

TypeinterventionalSponsorBrigham and Women's HospitalRan2019 to 2026Enrolled25,871ConditionsBone Density, Bone Health, FracturesArmsVitamin D3 placebo, Fish oil placebo, Omega-3 fatty acids (fish oil), Vitamin D3
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. The clinician's guide to prevention and treatment of osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Article
  6. Gut Microbiota in Bone Health and Diabetes.Current osteoporosis reports · 2021
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

A L GoldmanDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
C M DonlonDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
N R CookDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
J E MansonDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
J E BuringDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
T CopelandDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
C Y YuDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
M S LeBoffDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA. mleboff@bwh.harvard.edu.
Brigham and Women's Hospital · USHarvard University · US

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
VITamin D and omegA-3 triaL (VITAL)U01CA138962 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., MANSON, JOANN ELISABETH · 2009 to 2014
$23.6M
The VITamin D and OmegA-3 TriaL (VITAL)R01CA138962 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., MANSON, JOANN ELISABETH · 2015 to 2019
$20.9M
VITamin D and OmegA-3 TriaL (VITAL): Interrelationship of Vitamin D and Vitamin K on BoneR01AR059775 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LEBOFF, MERYL SUSAN · 2012 to 2022
$3.9M
VITamin D OmegA-3 TriaL (VITAL): Fractures, Vitamin D and Genetic MarkersR01AR070854 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LEBOFF, MERYL SUSAN · 2018 to 2022
$2.8M
Vitamin D and Omega-3 Fatty Acids(VITAL Trial): Effects on FracturesR01AR060574 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LEBOFF, MERYL SUSAN · 2010 to 2013
$779k
NCATS NIH HHS UL1 TR001102NCI NIH HHS R01 CA138962NCI NIH HHS U01 CA138962NIAMS NIH HHS R01 AR059775NIAMS NIH HHS R01 AR060574NIAMS NIH HHS R01 AR070854NIAMS NIH HHS R01AR59775
6 · The paper itself

Abstract

We investigated the association of clinical variables with TBS at baseline in the bone health sub-cohort of the VITamin D and OmegA-3 TriaL (VITAL). Lower TBS was associated with female sex, aging, BMI ≥ 25 kg/m

introductionWe investigated whether TBS differs by sex, race, body mass index (BMI), and other clinical variables.

methodsThe VITamin D and OmegA-3 TriaL (VITAL) is determining effects of vitamin D

resultsTBS was greater in men than women (1.311 vs. 1.278, P < 0.001) and lower with elevated BMIs (P < 0.001), higher age (P = 0.004), diabetes (P = 0.008), SSRI use (P = 0.044), and high alcohol intake (P = 0.009). There was a trend for history of fragility fractures (P = 0.072), and lower TBS. TBS did not vary when analyzed by race, smoking, history of falls, and multivitamin or caffeine use.

conclusionsLower TBS was associated with female sex, aging, BMI ≥ 25 kg/m

trial registrationNCT01747447.

Indexed as

Dietary SupplementsAbsorptiometry, PhotonAgedAged, 80 and overAgingBone DensityCancellous BoneCholecalciferolDouble-Blind MethodFatty Acids, Omega-3FemaleHumansMaleMiddle AgedSelective Serotonin Reuptake InhibitorsSex FactorsCholecalciferolFatty Acids, Omega-3Selective Serotonin Reuptake InhibitorsFractureOsteoporosisSSRITBSTrabecular bone score

Identifiers

PMID30022253
PMCPMC6193819
OpenAlexW2883522341

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.