ArticleScientific reports2018
Engineering the oleaginous red yeast Rhodotorula glutinis for simultaneous β-carotene and cellulase production.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Advances in microbial biofuel production by metabolic and enzyme engineering, synthetic biology, metagenomics, and genome editing applications.Emerging topics in life sciences · 2025Review
- Kingdom-wide CRISPR guide design with ALLEGRO.Nucleic acids research · 2025Article
- Article
- Proteomic insights into the physiology and metabolism of oleaginous yeasts and filamentous fungi.Frontiers in microbiology · 2025Review
- Exploration of carotenoid-producingCurrent research in microbial sciences · 2025Article
- Challenges and prospects of yeast-based microbial oil production within a biorefinery concept.Microbial cell factories · 2023Review
- Review
- Industrial-Scale Production of Mycotoxin Binder from the Red YeastJournal of fungi (Basel, Switzerland) · 2022Article
- Near Chromosome-Level Genome Assembly and Annotation ofJournal of fungi (Basel, Switzerland) · 2022Article
- Carotenoids and Their Biosynthesis in Fungi.Molecules (Basel, Switzerland) · 2022Review
- The history, state of the art and future prospects for oleaginous yeast research.Microbial cell factories · 2021Review
- Beta-carotene and its protective effect on gastric cancer.World journal of clinical cases · 2021Review
- Article
- Carotenoid-producing yeasts: Identification and Characteristics of Environmental Isolates with a Valuable Extracellular Enzymatic Activity.Microorganisms · 2019Article
- Optimization of submerged fermentation process for improved production of β-carotene byHeliyon · 2019Article
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Authors and funding
6 authors.
Funding
Abstract
Rhodotorula glutinis, an oleaginous red yeast, intrinsically produces several bio-products (i.e., lipids, carotenoids and enzymes) and is regarded as a potential host for biorefinery. In view of the limited available genetic engineering tools for this yeast, we have developed a useful genetic transformation method and transformed the β-carotene biosynthesis genes (crtI, crtE, crtYB and tHMG1) and cellulase genes (CBHI, CBHII, EgI, EgIII, EglA and BGS) into R. glutinis genome. The transformant P4-10-9-63Y-14B produced significantly higher β-carotene (27.13 ± 0.66 mg/g) than the wild type and also exhibited cellulase activity. Furthermore, the lipid production and salt tolerance ability of the transformants were unaffected. This is the first study to engineer the R. glutinis for simultaneous β-carotene and cellulase production. As R. glutinis can grow in sea water and can be engineered to utilize the cheaper substrates (i.e. biomass) for the production of biofuels or valuable compounds, it is a promising host for biorefinery.
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