ArticleNature2018
Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development.
Abstract read
In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 216 papers.
0numbers the graph read from it
0cells of the map it votes in
216citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
216 citing papers in PubMed.
- Olfactory Tuft Cells Are Critical to Basal Inflammation, Innate Immune Response to Viral Infection, and Modulation of Quiescent Stem Cell Activation, Proliferation and Differentiation.Cell proliferation · 2026Article
- Review
- Article
- Colorectal cancers with distinct metastatic potential trigger divergent early T cell responses.bioRxiv : the preprint server for biology · 2026Article
- Breaking the upper limit of mTEC heterogeneity.Nature immunology · 2026Article
- Thymic alveolar type 2 epithelial mimetic cells revealed by RUNX1 deficiency.Nature immunology · 2026Article
- ZFP36L1 and ZFP36L2 cooperatively regulate thymic epithelial cell function to prevent early-onset thymic involution.Cell death and differentiation · 2026Article
- Foxp1 controls Fezf2-dependent gene expression, mimetic mTEC diversity, and thymic central tolerance.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Runx3 instructs AireJournal of autoimmunity · 2026Article
- Gastrointestinal tuft cells: Recent insights and next questions.Science immunology · 2026Review
- From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology.Immunological reviews · 2026Review
- Multimerizing transcription factors FOXP3 and AIRE as chromatin architectural regulators.Nature immunology · 2026Review
- The Cell Ontology in the age of single-cell omics.Scientific data · 2026Article
- KLF2 controls thymic epithelial cell homeostasis, impacting regulatory T cell development and immune tolerance.iScience · 2026Article
- Morphometric analysis of the thymic epithelial cell network using integrated and orthogonal digital pathology approaches.Communications biology · 2026Article
- The structure and function of taste G protein-coupled receptors and their implications in diseases.International journal of oral science · 2026Review
- Network-orchestrated regulation of thymic dysfunction and restoration.Frontiers in immunology · 2026Review
- Fezf2 regulates differentiation of Aire-expressing and post-Aire mimetic epithelial populations maintaining thymic homeostasis.bioRxiv : the preprint server for biology · 2026Article
- AIRE transcriptional condensates in central tolerance: a multiscale mechanistic perspective.Frontiers in immunology · 2026Review
- Tuft cell-mediated pathogen sensing and inflammation resolution.Biochemical Society transactions · 2025Review
156 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
20 authors.
Corey N MillerDiabetes Center, University of California, San Francisco, San Francisco, CA, USA.
Irina ProektDiabetes Center, University of California, San Francisco, San Francisco, CA, USA.
Jakob von MoltkeDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Kristen L WellsDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Aparna R RajpurkarDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Haiguang WangCenter for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Kristin RattayDivision of Developmental Immunology, Tumor Immunology Program, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Imran S KhanDiabetes Center, University of California, San Francisco, San Francisco, CA, USA.
Todd C MetzgerDiabetes Center, University of California, San Francisco, San Francisco, CA, USA.
Joshua L PollackDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Adam C FriesBiological Imaging Development Center and Department of Pathology, University of California, San Francisco, CA, USA.
Wint W LwinDiabetes Center, University of California, San Francisco, San Francisco, CA, USA.
Eric J WigtonDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.
Audrey V ParentDiabetes Center, University of California, San Francisco, San Francisco, CA, USA.
Bruno KyewskiDivision of Developmental Immunology, Tumor Immunology Program, German Cancer Research Center (DKFZ), Heidelberg, Germany.
David J ErleDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Kristin A HogquistCenter for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Lars M SteinmetzDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Richard M LocksleyDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Mark S AndersonDiabetes Center, University of California, San Francisco, San Francisco, CA, USA. mark.anderson@ucsf.edu.
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6MRole of miRNAs in Th2-Driven inflammation in AsthmaP01HL107202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANSEL, KARL MARK · 2012 to 2023
$23.3MResearch BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 2003 to 2019
$21.8MGENETICS TRAINING PROGRAM FOR PHD CANDIDATEST32GM007790 · NIGMS · STANFORD UNIVERSITY · PI BRUNET, ANNE, KINGSLEY, DAVID M · 1985 to 2020
$12.8MMOLECULAR AND CELLULAR IMMUNOLOGYT32AI007334 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CYSTER, JASON G · 1988 to 2023
$11.0MThymic medullary epithelial cell turnover and control of immune toleranceR37AI097457 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mark S Anderson · 2017 to 2026
$4.0MParasite immunity orchestrated by type 2 immune cellsR01AI026918 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOCKSLEY, RICHARD M · 1988 to 2022
$3.8MTCR signal strength in thymic selectionR37AI039560 · NIAID · UNIVERSITY OF MINNESOTA · PI HOGQUIST, KRISTIN A. · 2012 to 2021
$3.7MUsing human stem cell-derived thymic epithelium to remodel T1D immune toleranceU01DK107383 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S, BLUESTONE, JEFFREY A · 2016 to 2019
$2.3MThymic medullary epithelial cell turnover and control of immune toleranceR01AI097457 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 2012 to 2016
$1.9MBD FACSAria Fusion Cell SorterS10OD021822 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, MICHAEL R. · 2016 to 2016
$573kNHLBI NIH HHS P01 HL107202NIAID NIH HHS R01 AI026918NIAID NIH HHS R01 AI097457NIAID NIH HHS R37 AI039560NIAID NIH HHS R37 AI097457NIAID NIH HHS T32 AI007334NIDDK NIH HHS P30 DK063720NIDDK NIH HHS U01 DK107383NIGMS NIH HHS T32 GM007618NIGMS NIH HHS T32 GM007790NIH HHS S10 OD021822
Abstract
The thymus is responsible for generating a diverse yet self-tolerant pool of T cells
Indexed as
AIRE ProteinAnimalsCellular MicroenvironmentDoublecortin-Like KinasesEpithelial CellsFemaleHumansImmune ToleranceInterleukin-4InterleukinsIntracellular Signaling Peptides and ProteinsMaleMiceMice, Inbred BALB CMice, Inbred C57BLProtein Serine-Threonine KinasesAIRE ProteinDCLK1 protein, humanDclk1 protein, mouseDoublecortin-Like KinasesInterleukin-4InterleukinsIntracellular Signaling Peptides and ProteinsMydgf protein, mouseProtein Serine-Threonine KinasesTranscription FactorsTRPM5 protein, humanTRPM Cation Channels
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.