Evidence map›Paper›PMID 30022160›Full record

ArticleNature2018

The outer membrane is an essential load-bearing element in Gram-negative bacteria.

Enrique R Rojas, Gabriel Billings, Pascal D Odermatt, George K Auer, Lillian Zhu, Amanda Miguel, Fred Chang, Douglas B Weibel, Julie A Theriot, Kerwyn Casey Huang

Open access · greenAbstract read
In one paragraph

Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 303 papers.

0numbers the graph read from it
0cells of the map it votes in
303citing papers in PubMed
37.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

303 citing papers in PubMed, 617 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. LPS in gram-negative bacterial growth and physiology: outside but fully integrated.Microbiology and molecular biology reviews : MMBR · 2026
    Review
  6. Article
  7. Article
  8. Article
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  11. Article
  12. Article
  13. Review
  14. Journal of bacteriology · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

243 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Enrique R RojasDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Gabriel BillingsDepartment of Physics, Stanford University, Stanford, CA, USA.
Pascal D OdermattDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
George K AuerDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA.
Lillian ZhuDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Amanda MiguelDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Fred ChangDepartment of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, USA.
Douglas B WeibelDepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA.
Julie A TheriotDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.
Kerwyn Casey HuangDepartment of Bioengineering, Stanford University, Stanford, CA, USA. kchuang@stanford.edu.
Stanford University · USUniversity of California, San Francisco · USUniversity of Wisconsin–Madison · USHoward Hughes Medical Institute · US

Funding

Physics-based Simulation of Biological Structures(RMI)U54GM072970 · NIGMS · STANFORD UNIVERSITY · PI ALTMAN, RUSS BIAGIO · 2004 to 2013
$33.5M
TRAINING & OUTREACH COREP50GM107615 · NIGMS · STANFORD UNIVERSITY · PI FERRELL, JAMES E. · 2013 to 2017
$10.9M
ASSEMBLY AND PLACEMENT OF THE CELL DIVISION RINGR01GM056836 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHANG, FRED · 1998 to 2018
$7.4M
Actin-Based Motility of a Bacterial PathogenR37AI036929 · NIAID · UNIVERSITY OF WASHINGTON · PI THERIOT, JULIE A. · 2010 to 2019
$3.0M
Engineering of cell shape and intracellular organizationDP2OD006466 · OD · STANFORD UNIVERSITY · PI HUANG, KERWYN C. · 2009 to 2009
$2.4M
Revisiting the bacterial cell wall as a target for new antibioticsDP2OD008735 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI WEIBEL, DOUGLAS BENJAMIN · 2011 to 2011
$2.3M
Howard Hughes Medical InstituteNIAID NIH HHS R37 AI036929NIGMS NIH HHS P50 GM107615NIGMS NIH HHS R01 GM056836NIGMS NIH HHS U54 GM072970NIH HHS DP2 OD006466NIH HHS DP2 OD008735
6 · The paper itself

Abstract

Gram-negative bacteria possess a complex cell envelope that consists of a plasma membrane, a peptidoglycan cell wall and an outer membrane. The envelope is a selective chemical barrier

Indexed as

Cell MembraneCell WallDetergentsEscherichia coliGram-Negative BacteriaMicrobial ViabilityWeight-BearingDetergents

Identifiers

PMID30022160
PMCPMC6089221
OpenAlexW2884934298

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.