ArticleScientific reports2018
Menthol, a unique urinary volatile compound, is associated with chronic inflammation in interstitial cystitis.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Bridging the Gap: Harnessing Plant Bioactive Molecules to Target Gut Microbiome Dysfunctions in Amyotrophic Lateral Sclerosis.Current issues in molecular biology · 2024Review
- Dietary Peppermint Extract Inhibits Chronic Heat Stress-Induced Activation of Innate Immunity and Inflammatory Response in the Spleen of Broiler Chickens.Animals : an open access journal from MDPI · 2024Article
- Essential Oils: Chemistry and Pharmacological Activities.Biomolecules · 2023Review
- Article
- Cold stimuli, hot topic: An updated review on the biological activity of menthol in relation to inflammation.Frontiers in immunology · 2022Review
- Protein profiling in the habenula after chronic (-)-menthol exposure in mice.Journal of neurochemistry · 2021Article
- Adenosine AJournal of inflammation research · 2021Article
- Anti-Hyperalgesic Properties of Menthol and Pulegone.Frontiers in pharmacology · 2021Article
- A Descriptive Overview of the Medical Uses Given toBiology · 2020Review
- Metabolomic and lipidomic approaches to identify biomarkers for bladder cancer and interstitial cystitis (Review).Molecular medicine reports · 2020Review
- Eucalyptus essential oils inhibit the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages through reducing MAPK and NF-κB pathways.BMC complementary medicine and therapies · 2020Article
- Metabolomics in Central Sensitivity Syndromes.Metabolites · 2020Review
- Article
- Classification of the urinary metabolome using machine learning and potential applications to diagnosing interstitial cystitis.Bladder (San Francisco, Calif.) · 2020Article
- Behavioural Response Alteration inBiomarkers in cancer · 2019Article
- Protective Effects of Chinese Traditional Medicine Longhu Rendan against Atherosclerosis via Negative Regulation of LOX-1.Evidence-based complementary and alternative medicine : eCAM · 2018Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Chronic inflammation is a potential systemic risk factor for many bladder dysfunctions, including interstitial cystitis (IC). However, the underlying mechanism through which a healthy bladder protects itself from inflammatory triggers remains unknown. In this study, we identified odor compounds in urine obtained from IC patients and healthy controls. Using comprehensive solid-phase microextraction-gas chromatography-time-of-flight-mass spectrometry (SPME-GC-TOF-MS) profiling and bioinformatics, we found that levels of urinary volatile metabolites, such as menthol, were significantly reduced in IC patients, compared to healthy controls. In an attempt to understand the mechanistic meaning of our volatile metabolites data and the role of menthol in the immune system, we performed two independent experiments: (a) cytokine profiling, and (b) DNA microarray. Our findings suggest that lipopolysaccharide (LPS)-stimulated inflammatory events, such as the production and secretion of inflammatory cytokines (e.g., TNF-α, IL-6, and IL-1β) and the activation of NF-κB and associated proteins within a large signaling network (e.g., Akt, TLR1, TNFAIP3, and NF-κB), are suppressed by the presence of menthol. These findings broaden our knowledge on the role of urinary menthol in suppressing inflammatory events and provide potential new strategies for alleviating both the odor and inflammation associated with IC.
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