ArticleScientific reports2018
How different sterols contribute to saponin tolerant plasma membranes in sea cucumbers.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Triterpene Glycosides from the Sea CucumberMarine drugs · 2026Article
- Sterol divergence across eukaryotic kingdoms determines membrane susceptibility to saponins, a class of plant defense compounds.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Structural Characterization and Profiles of Saponins from Two Algerian Sea Cucumbers.Molecules (Basel, Switzerland) · 2024Article
- Botrytis cinerea combines four molecular strategies to tolerate membrane-permeating plant compounds and to increase virulence.Nature communications · 2024Article
- Horse Chestnut Saponins-Escins, Isoescins, Transescins, and Desacylescins.Molecules (Basel, Switzerland) · 2023Article
- Biosynthesis of saponin defensive compounds in sea cucumbers.Nature chemical biology · 2022Article
- Impact of the Hydrolysis and Methanolysis of BidesmosidicMolecules (Basel, Switzerland) · 2022Article
- Anticancer and anticholesterol attributes of sea cucumbers: An opinion in terms of functional food applications.Frontiers in nutrition · 2022Article
- Sitosterol and glucosylceramide cooperative transversal and lateral uneven distribution in plant membranes.Scientific reports · 2021Article
- Article
- Echinoderms Metabolites: Structure, Functions, and Biomedical Perspectives.Marine drugs · 2021Article
- Enhancing the Membranolytic Activity ofMolecules (Basel, Switzerland) · 2020Article
- Triterpenoids in Echinoderms: Fundamental Differences in Diversity and Biosynthetic Pathways.Marine drugs · 2019Review
- The activity of the saponin ginsenoside Rh2 is enhanced by the interaction with membrane sphingomyelin but depressed by cholesterol.Scientific reports · 2019Article
- α-hederin induces autophagic cell death in colorectal cancer cells through reactive oxygen species dependent AMPK/mTOR signaling pathway activation.International journal of oncology · 2019Article
- Evolution of Structural Diversity of Triterpenoids.Frontiers in plant science · 2019Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Sea cucumbers produce saponins as a chemical defense mechanism, however their cells can tolerate the cytotoxic nature of these chemicals. To elucidate the molecular mechanisms behind this tolerance a suite of complementary biophysical tools was used, firstly using liposomes for in vitro techniques then using in silico approaches for a molecular-level insight. The holothuroid saponin Frondoside A, caused significantly less permeabilization in liposomes containing a Δ
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Registered trials
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