ArticleScientific reports2018
Dynamic Loading and Tendon Healing Affect Multiscale Tendon Properties and ECM Stress Transmission.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 74 citations in OpenAlex.
- Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review.Advanced healthcare materials · 2026Review
- Tendon-Targeted Knockout of Collagen XII Disrupts Murine Achilles Tendon Structure, Function, and Gene Expression at Later Stages of Postnatal Development.Annals of biomedical engineering · 2026Article
- The effect of microstructural variations in tendon and ligament on diffusion tensor MRI.bioRxiv : the preprint server for biology · 2026Article
- What Is the Clinical Efficacy of Combined Semitendinosus Autograft Reconstruction and Scar Tissue Repair for Chronic Irreparable Patellar Tendon Rupture?Clinical orthopaedics and related research · 2025Article
- Screening of hub genes and immunocytes related to tendon injury based on bioinformatics and machine learning models.Scientific reports · 2025Article
- ESWT is able to change macromorphological and micromorphological parameters in patellar tendinopathy: a prospective cohort study.International journal of surgery (London, England) · 2025Article
- Muscle Contraction Is Essential for Tendon Healing and Muscle Function Recovery After Achilles Tendon Rupture and Surgical Repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Editorial: Effect of mechanical loading on the tendon for tissue engineering approaches.Frontiers in bioengineering and biotechnology · 2025Article
- Tendon mechanobiology in the context of tendon biofabrication.Frontiers in bioengineering and biotechnology · 2025Review
- Human Tendon-on-Chip: Unveiling the Effect of Core Compartment-T Cell Spatiotemporal Crosstalk at the Onset of Tendon Inflammation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Augmentation of Tendon and Ligament Repair with Fiber-Reinforced Hydrogel Composites.Advanced healthcare materials · 2024Review
- Deprivation of loading during rat Achilles tendon healing affects extracellular matrix composition and structure, and reduces cell density and alignment.Scientific reports · 2024Article
- Collagen denaturation in post-run Achilles tendons and Achilles tendinopathy: In vivo mechanophysiology and magnetic resonance imaging.Science advances · 2024Article
- Article
- Review
- Overload in a Rat In Vivo Model of Synergist Ablation Induces Tendon Multiscale Structural and Functional Degeneration.Journal of biomechanical engineering · 2023Article
- The application of mechanical load onto mouse tendons by magnetic restraining represses Mmp-3 expression.BMC research notes · 2023Article
- Mechanics and differential healing outcomes of small and large defect injuries of the tendon-bone attachment in the rat rotator cuff.Connective tissue research · 2023Article
- Transcriptome and co-expression network analysis reveals the molecular mechanism of inosine monophosphate-specific deposition in chicken muscle.Frontiers in physiology · 2023Article
- Natural, synthetic and commercially-available biopolymers used to regenerate tendons and ligaments.Bioactive materials · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The extracellular matrix (ECM) is the primary biomechanical environment that interacts with tendon cells (tenocytes). Stresses applied via muscle contraction during skeletal movement transfer across structural hierarchies to the tenocyte nucleus in native uninjured tendons. Alterations to ECM structural and mechanical properties due to mechanical loading and tissue healing may affect this multiscale strain transfer and stress transmission through the ECM. This study explores the interface between dynamic loading and tendon healing across multiple length scales using living tendon explants. Results show that macroscale mechanical and structural properties are inferior following high magnitude dynamic loading (fatigue) in uninjured living tendon and that these effects propagate to the microscale. Although similar macroscale mechanical effects of dynamic loading are present in healing tendon compared to uninjured tendon, the microscale properties differed greatly during early healing. Regression analysis identified several variables (collagen and nuclear disorganization, cellularity, and F-actin) that directly predict nuclear deformation under loading. Finite element modeling predicted deficits in ECM stress transmission following fatigue loading and during healing. Together, this work identifies the multiscale response of tendon to dynamic loading and healing, and provides new insight into microenvironmental features that tenocytes may experience following injury and after cell delivery therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.