ArticleScientific reports2018
Mechanical interactions between bacteria and hydrogels.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- Selective Covalent Assembly of Gram-Negative Bacteria and Synthetic Polymers into Functional Living Materials.Journal of the American Chemical Society · 2026Article
- 3D-Bioprinted Marine Bacteria for the Degradation of Polyhydroxybutyrate Bioplastics.ACS applied polymer materials · 2026Article
- Bacterial ghosts embedded in natural hydrogels as drug delivery vehicles for cancer treatment.RSC advances · 2026Article
- Assessment of Antibiotic Sensitivity in Biofilms Using GelMA Hydrogel Microspheres.Gels (Basel, Switzerland) · 2026Article
- Synthetic soils for ecological and synthetic biology applications.FEMS microbiology reviews · 2026Review
- Biophysics of Bacterial Colonial Structures and the Occupancy of Microecological Spaces.Biology · 2025Review
- In Vitro Evaluation of a Gelatin Type A/PVA Hydrogel Functionalized with Roasted Green Tea (Gels (Basel, Switzerland) · 2025Article
- Hydrogel-based experimental models of the gastrointestinal tract.Microbiome · 2025Review
- Light-stimulated smart thermo-responsive constructs for enhanced wound healing: A streamlined command approach.Asian journal of pharmaceutical sciences · 2025Article
- Adaptations of Gram-Negative and Gram-Positive Probiotic Bacteria in Engineered Living Materials.ACS biomaterials science & engineering · 2025Article
- Bacterial Adhesion on Soft Surfaces: The Dual Role of Substrate Stiffness and Bacterial Growth Stage.Microorganisms · 2025Article
- The landscape of biofilm models for phage therapy: mimicking biofilms in diabetic foot ulcers using 3D models.Frontiers in microbiology · 2025Review
- Review
- Cyclic Stretching Triggers Cell Orientation and Extracellular Matrix Remodeling in a Periodontal Ligament 3D In Vitro Model.Advanced healthcare materials · 2023Article
- Dissolvable alginate hydrogel-based biofilm microreactors for antibiotic susceptibility assays.Biofilm · 2023Article
- Motility mediates satellite formation in confined biofilms.The ISME journal · 2023Article
- Gene expression dynamics in input-responsive engineered living materials programmed for bioproduction.Materials today. Bio · 2023Article
- Glycerol Droplet Spreading on Growing Bacillus Subtilis Biofilms.Micromachines · 2023Article
- Sprayable biofilm - Agarose hydrogels as 3D matrix for enhanced productivity in bioelectrochemical systems.Biofilm · 2022Article
- Intra-colony channel morphology inBiofilm · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Mechanical interactions between bacterial cells and extracellular polymeric substance are essential in determining biofilm assembly and disassembly as well the mechanical characteristics of biofilms. However, the physics of these mechanical interactions in different cell culture conditions are poorly understood. We created typical artificial biofilm consisting of planktonic bacteria and hydrogel, in the absence of metabolic or regulatory effect. We have demonstrated that the cell culture medium can significantly affect the mechanical interactions between bacterial cells and hydrogels. The stiffness of the bacteria-hydrogel artificial biofilm cannot be simply attributed by the summation of the contribution from the bacteria and hydrogel based on the mathematical models and computational models. We have revealed that the tryptone component of Luria-Bertani broth medium plays an important role in stiffening effect of bacteria-hydrogel construct. Such significant stiffening effect can be explained by the following mechanism: the presence of tryptone in cell culture medium may enable the bacteria itself to crosslink the hydrogel polymer chains. Our findings have also demonstrated the synergy of modelling and innovative experiments which would potentially impact the biofilm control strategies.
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