Evidence map›Paper›PMID 30022042›Full record

ArticleMolecular psychiatry2020

Nitrated meat products are associated with mania in humans and altered behavior and brain gene expression in rats.

Seva G Khambadkone, Zachary A Cordner, Faith Dickerson, Emily G Severance, Emese Prandovszky, Mikhail Pletnikov, Jianchun Xiao, Ye Li, Gretha J Boersma, C Conover Talbot and 6 more

Abstract read
In one paragraph

Article in Molecular psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
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  6. Review
  7. Article
  8. Potential Use ofAnimals : an open access journal from MDPI · 2020
    Article
  9. Mania and nitrated meat products.Molecular psychiatry · 2020
    Article
  10. Review
  11. Review
  12. Seeking the Psilocybiome: Psychedelics meet the microbiota-gut-brain axis.International journal of clinical and health psychology : IJCHP
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Seva G KhambadkoneDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Zachary A CordnerDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-6000-567X
Faith DickersonSheppard Pratt Health System, Baltimore, MD, USA.
Emily G SeveranceDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Emese PrandovszkyDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mikhail PletnikovDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Jianchun XiaoDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ye LiDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gretha J BoersmaDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
C Conover TalbotInstitute for Basic Biomedical Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Wayne W CampbellDepartment of Nutrition Science, Purdue University, West Lafayette, IN, USA.
Christian S WrightDepartment of Nutrition Science, Purdue University, West Lafayette, IN, USA.
C Evan SipleMobtown Meatsnacks, Baltimore, MD, USA.
Timothy H MoranDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Kellie L TamashiroDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Robert H YolkenDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. rhyolken@gmail.com.
Johns Hopkins University · USPurdue University West Lafayette · USSheppard Pratt Health System · US

Funding

Project 3P50MH094268 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2011 to 2020
$19.9M
Mutant DISC 1 and Abnormal Neurodevelopment in Mental IllnessR01MH083728 · NIMH · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI PLETNIKOV, MIKHAIL V · 2009 to 2020
$4.9M
Molecular mechanism of astrocytic vulnerability to adolescent cannabis useR01DA041208 · NIDA · JOHNS HOPKINS UNIVERSITY · PI KAMIYA, ATSUSHI, PLETNIKOV, MIKHAIL V · 2016 to 2020
$2.9M
NIDA NIH HHS R01 DA041208NIMH NIH HHS P50 MH094268NIMH NIH HHS R01 MH083728
6 · The paper itself

Abstract

Mania is a serious neuropsychiatric condition associated with significant morbidity and mortality. Previous studies have suggested that environmental exposures can contribute to mania pathogenesis. We measured dietary exposures in a cohort of individuals with mania and other psychiatric disorders as well as in control individuals without a psychiatric disorder. We found that a history of eating nitrated dry cured meat but not other meat or fish products was strongly and independently associated with current mania (adjusted odds ratio 3.49, 95% confidence interval (CI) 2.24-5.45, p < 8.97 × 10

Indexed as

AdultAnimalsBipolar DisorderBrainFemaleHumansHyperkinesisMaleManiaMeat ProductsNitratesRatsRats, Sprague-DawleyNitrates

Identifiers

PMID30022042
PMCPMC7077736
OpenAlexW2876186620

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.