Evidence map›Paper›PMID 30021901›Full record

ArticleJournal of virology2018

Testicular Degeneration and Infertility following Arbovirus Infection.

Giantonella Puggioni, Davide Pintus, Eleonora Melzi, Giorgio Meloni, Angela Maria Rocchigiani, Caterina Maestrale, Daniela Manunta, Giovanni Savini, Maria Dattena, Annalisa Oggiano and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
8.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Giantonella PuggioniIstituto Zooprofilattico Sperimentale della Sardegna, Sassari, Italy.
Davide PintusIstituto Zooprofilattico Sperimentale della Sardegna, Sassari, Italy.
Eleonora MelziMRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
Giorgio MeloniIstituto Zooprofilattico Sperimentale della Sardegna, Sassari, Italy.
Angela Maria RocchigianiIstituto Zooprofilattico Sperimentale della Sardegna, Sassari, Italy.
Caterina MaestraleIstituto Zooprofilattico Sperimentale della Sardegna, Sassari, Italy.
Daniela ManuntaIstituto Zooprofilattico Sperimentale della Sardegna, Sassari, Italy.
Giovanni SaviniIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise, OIE Reference Laboratory for BTV, Teramo, Italy.
Maria DattenaAGRIS, Dipartimento per la Ricerca nelle Produzioni Animali, Olmedo, Italy.
Annalisa OggianoIstituto Zooprofilattico Sperimentale della Sardegna, Sassari, Italy.
Massimo PalmariniMRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
Ciriaco LigiosIstituto Zooprofilattico Sperimentale della Sardegna, Sassari, Italy ciriaco.ligios@izs-sardegna.it.
Istituto Zooprofilattico Sperimentale della Sardegna · ITMRC University of Glasgow Centre for Virus Research · GBIstituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale · ITSardegna Agricoltura · IT

Funding

Medical Research Council MC_UU_12014/10Wellcome Trust
6 · The paper itself

Abstract

Arboviruses can cause a variety of clinical signs, including febrile illness, arthritis, encephalitis, and hemorrhagic fever. The recent Zika epidemic highlighted the possibility that arboviruses may also negatively affect the male reproductive tract. In this study, we focused on bluetongue virus (BTV), the causative agent of bluetongue and one of the major arboviruses of ruminants. We show that rams that recovered from bluetongue displayed signs of testicular degeneration and azoospermia up to 100 days after the initial infection. Importantly, testicular degeneration was induced in rams experimentally infected with either a high (BTV-1

Indexed as

SpermatogenesisAnimalsBluetongueBluetongue virusEndothelium, VascularInfertility, MaleMaleSheepSheep DiseasesTestisTestosteroneVirulenceVirus ReplicationTestosteronearbovirusbluetongue virusinfertilitysheep

Identifiers

PMID30021901
PMCPMC6146814
OpenAlexW2884747555

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.