ArticleBiology letters2018
Efficacy of negative feedback in the HPA axis predicts recovery from acute challenges.
Article in Biology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- When Does Stress Build Strength? Linking Stress Physiology to Resilience in the Age of Rapid Environmental Change.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Physiological responses of wild birds to artificial grass during introduction to laboratory housing.PeerJ · 2025Article
- Activation of the sympathetic-adrenal-medullary system increases DNA damage during the transition to captivity.Integrative organismal biology (Oxford, England) · 2025Article
- Recovery through resistance? nesting urban female song sparrows (Frontiers in physiology · 2025Article
- Glucocorticoids and land cover: a largescale comparative approach to assess a physiological biomarker for avian conservation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Among-species variation in hormone concentrations is associated with urban tolerance in birds.Proceedings. Biological sciences · 2022Article
- Are individuals consistent? Endocrine reaction norms under different ecological challenges.The Journal of experimental biology · 2021Article
- Inferring Whole-Organism Metabolic Rate From Red Blood Cells in Birds.Frontiers in physiology · 2021Article
- Environmental unpredictability shapes glucocorticoid regulation across populations of tree swallows.Scientific reports · 2020Article
- Kinetics of Physiological and Behavioural Responses in Endotoxemic Pigs with or without Dexamethasone Treatment.International journal of molecular sciences · 2019Article
- Efficacy of negative feedback in the HPA axis predicts recovery from acute challenges.Biology letters · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The glucocorticoid stress response mediates a suite of physiological and behavioural changes that allow vertebrates to cope with transient stressors. Chronically elevated glucocorticoid levels are known to result in a variety of organismal costs, but relatively little is known about the downstream effects of mounting a series of brief, acute spikes in circulating glucocorticoids. Conceptual models of stress suggest that repeated acute stressors might produce 'wear-and-tear' on the stress-response system when encountered in sequence. We used a novel technique to experimentally induce acute corticosterone spikes on either three or six consecutive days in incubating tree swallows. Consistent with the 'wear-and-tear' hypothesis, we found that (i) a sequence of corticosterone spikes produced cumulative effects on corticosterone regulation, (ii) treatment frequency predicted the severity of consequences, and (iii) individual variation in the ability to terminate the stress response through negative feedback predicted the duration of physiological disruption in the group that experienced the most frequent challenges. Our results illustrate the importance of assessing multiple aspects of the hormonal stress response and have implications for understanding both individual and population resilience to repeated transient stressors.
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