Evidence map›Paper›PMID 30021854›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Enhanced expression of MycN/CIP2A drives neural crest toward a neural stem cell-like fate: Implications for priming of neuroblastoma.

Laura Kerosuo, Pushpa Neppala, Jenny Hsin, Sofie Mohlin, Felipe Monteleone Vieceli, Zsofia Török, Anni Laine, Jukka Westermarck, Marianne E Bronner

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 52 citations in OpenAlex.

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  12. Epigenetic Dysregulation inInternational journal of molecular sciences · 2023
    Review
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  18. Recent advances in the developmental origin of neuroblastoma: an overview.Journal of experimental & clinical cancer research : CR · 2022
    Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Laura KerosuoDepartment of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Pushpa NeppalaDepartment of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Jenny HsinDepartment of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Sofie MohlinPediatric Oncology, Department of Clinical Sciences Lund, Lund University, SE-22381 Lund, Sweden.ORCID 0000-0002-2458-3963
Felipe Monteleone VieceliDepartment of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Zsofia TörökDepartment of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Anni LaineTurku Centre for Biotechnology, University of Turku and Åbo Akademi University, FI-20014 Turku, Finland.
Jukka WestermarckTurku Centre for Biotechnology, University of Turku and Åbo Akademi University, FI-20014 Turku, Finland.
Marianne E BronnerDepartment of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125; mbronner@caltech.edu.ORCID 0000-0003-4274-1862
California Institute of Technology · USÅbo Akademi University · FILund University · SE

Funding

Transcriptional Casualty in Embryonic Morphogenesis: from the Specifications GRNP01HD037105 · NICHD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI DAVIDSON, ERIC H · 1999 to 2018
$27.1M
Neural Crest Development and DiseaseZIADE000748 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI KEROSUO, LAURA · 2018 to 2025
$11.5M
Gene Regulatory Network Controlling Premigratory Cranial vs Trunk Neural CrestR01DE024157 · NIDCR · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI BRONNER, MARIANNE · 2014 to 2025
$4.0M
NICHD NIH HHS P01 HD037105NIDCR NIH HHS R01 DE024157
6 · The paper itself

Abstract

Neuroblastoma is a neural crest-derived childhood tumor of the peripheral nervous system in which MycN amplification is a hallmark of poor prognosis. Here we show that

Indexed as

AutoantigensCell MovementHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsNeural CrestNeural Stem CellsNeuroblastomaN-Myc Proto-Oncogene ProteinSOXB1 Transcription FactorsAutoantigensCIP2A protein, humanIntracellular Signaling Peptides and ProteinsMembrane ProteinsMYCN protein, humanN-Myc Proto-Oncogene ProteinSOX2 protein, humanSOXB1 Transcription FactorsCIP2AMycNneural crestneuroblastoma initiationSox2

Identifiers

PMID30021854
PMCPMC6077707
OpenAlexW2883579506

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.