Evidence map›Paper›PMID 30021845›Full record

ArticleCirculation2018

Lipoprotein Particle Profiles, Standard Lipids, and Peripheral Artery Disease Incidence.

Aaron W Aday, Patrick R Lawler, Nancy R Cook, Paul M Ridker, Samia Mora, Aruna D Pradhan

2 registry-linked trialsOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 73 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 4 pooled it
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00000479 phase3completednot on this map

Women's Health Study of Low-dose Aspirin and Vitamin E in Apparently Healthy Women

TypeinterventionalSponsorBrigham and Women's HospitalRan1992 to 2005Enrolled39,876ConditionsCardiovascular Diseases, Cerebrovascular Disorders, Coronary Disease, Heart DiseasesArmsAspirin, Vitamin E, Placebo
NCT06061211 nacompletednot on this mapstarted 2023, after this paper: background citation

Treadmill Training with TENS Impact on Walking Distance, Pain and Peak Velocity in Patients with Peripheral Arterial Disease

TypeinterventionalSponsorCairo UniversityRan2023 to 2024Enrolled50ConditionsPeripheral Arterial DiseaseArmsTREADMILL(SIDEA-Germany treadmill ) with TENS
3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 4 syntheses or guidelines pooled it, 137 citations in OpenAlex.

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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Aaron W AdayDivision of Preventive Medicine (A.W.A., N.R.C., P.M.R., S.M., A.D.P.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Patrick R LawlerPeter Munk Cardiac Centre, University Health Network and the Heart and Stroke Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto, Canada (P.R.L.).
Nancy R CookDivision of Preventive Medicine (A.W.A., N.R.C., P.M.R., S.M., A.D.P.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Paul M RidkerDivision of Preventive Medicine (A.W.A., N.R.C., P.M.R., S.M., A.D.P.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Samia MoraDivision of Preventive Medicine (A.W.A., N.R.C., P.M.R., S.M., A.D.P.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Aruna D PradhanDivision of Preventive Medicine (A.W.A., N.R.C., P.M.R., S.M., A.D.P.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Brigham and Women's Hospital · USUniversity Health Network · CA

Funding

Women's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2M
Training Program in the Epidemiology of CVDT32HL007575 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BURING, JULIE E., RIDKER, PAUL M. · 1985 to 2019
$5.0M
Women's Health Study: Continued Follow-UpR01HL080467 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E. · 2005 to 2010
$4.5M
The Women's Health Study: Infrastructure Support for Continued Cohort Follow-upUM1CA182913 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 2014 to 2018
$4.0M
Total plasma and IgG glycomes, statin therapy and ASCVD eventsR01HL117861 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MORA, SAMIA · 2013 to 2022
$3.8M
TRIAL OF VITAMIN E, BETA-CAROTENE &ASPRIN IN WOMENR01HL043851 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E · 1991 to 2000
$1.6M
The Women's Health Study: Addition of New Data to Maximize its Research ImpactRC1HL099355 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E. · 2009 to 2010
$992k
New Gene Discoveries and Biology of Ribosomes in Diamond-Blackfan AnemiaK02HL111156 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI GAZDA, HANNA TERESA · 2012 to 2016
$568k
NCI NIH HHS R01 CA047988NCI NIH HHS UM1 CA182913NHLBI NIH HHS K02 HL111156NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL080467NHLBI NIH HHS R01 HL117861NHLBI NIH HHS RC1 HL099355NHLBI NIH HHS T32 HL007575
6 · The paper itself

Abstract

backgroundDespite strong and consistent prospective associations of elevated low-density lipoprotein (LDL) cholesterol concentration with incident coronary and cerebrovascular disease, data for incident peripheral artery disease (PAD) are less robust. Atherogenic dyslipidemia characterized by increased small LDL particle (LDL-P) concentration, rather than total LDL cholesterol content, along with elevated triglyceride-rich lipoproteins and low high-density lipoprotein (HDL) cholesterol (HDL-C), may be the primary lipid driver of PAD risk.

methodsThe study population was a prospective cohort study of 27 888 women ≥45 years old free of cardiovascular disease at baseline and followed for a median of 15.1 years. We tested whether standard lipid concentrations, as well as nuclear magnetic resonance spectroscopy-derived lipoprotein measures, were associated with incident symptomatic PAD (n=110) defined as claudication and/or revascularization.

resultsIn age-adjusted analyses, while LDL cholesterol was not associated with incident PAD, we found significant associations for increased total and small LDL-P concentrations, triglycerides, and concentrations of very LDL (VLDL) particle (VLDL-P) subclasses, increased total cholesterol (TC):HDL-C, low HDL-C, and low HDL particle (HDL-P) concentration (all P for extreme tertile comparisons <0.05). Findings persisted in multivariable-adjusted models comparing extreme tertiles for elevated total LDL-P (adjusted hazard ratio [HR

conclusionsIn this prospective study, nuclear magnetic resonance-derived measures of LDL-P, but not LDL cholesterol, were associated with incident PAD. Other features of atherogenic dyslipidemia, including elevations in TC:HDL-C, elevations in triglyceride-rich lipoproteins, and low standard and nuclear magnetic resonance-derived measures of HDL, were significant risk determinants. These data help clarify prior inconsistencies and may elucidate a unique lipoprotein signature for PAD compared to coronary and cerebrovascular disease. CLINICAL

trial registrationURL: https://www.clinicaltrials.gov/ . Unique Identifier: NCT00000479.

Indexed as

Cholesterol, HDLCholesterol, LDLFemaleHumansIncidenceLipoproteinsLipoproteins, HDLLipoproteins, VLDLMiddle AgedNuclear Magnetic Resonance, BiomolecularPeripheral Arterial DiseaseProportional Hazards ModelsProspective StudiesRisk FactorsUnited StatesCholesterol, HDLCholesterol, LDLLipoproteinsLipoproteins, HDLLipoproteins, VLDLcoronary artery diseaselipoproteinsmagnetic resonance spectroscopyperipheral artery disease

Identifiers

PMID30021845
PMCPMC6343136
OpenAlexW2901244157

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.