Evidence map›Paper›PMID 30021840›Full record

ArticleThe Journal of biological chemistry2018

Iron-dependent cleavage of ribosomal RNA during oxidative stress in the yeast

Jessica A Zinskie, Arnab Ghosh, Brandon M Trainor, Daniel Shedlovskiy, Dimitri G Pestov, Natalia Shcherbik

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. The function of Mak16 in ribosome biogenesis depends on its [4Fe-4S] cluster.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  5. Review
  6. TRMT1L-catalyzed mCell reports · 2025
    Article
  7. Organelle abnormalities in Alzheimer's disease.Organelle (Tucson, Ariz.) · 2025
    Article
  8. Article
  9. TRMT1L-catalyzed mbioRxiv : the preprint server for biology · 2024
    Article
  10. Ribosome Assembly and Repair.Annual review of cell and developmental biology · 2024
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jessica A ZinskieFrom the Department of Cell Biology and Neuroscience and.
Arnab GhoshFrom the Department of Cell Biology and Neuroscience and.
Brandon M TrainorFrom the Department of Cell Biology and Neuroscience and.
Daniel ShedlovskiyFrom the Department of Cell Biology and Neuroscience and.
Dimitri G PestovFrom the Department of Cell Biology and Neuroscience and.
Natalia ShcherbikFrom the Department of Cell Biology and Neuroscience and shcherna@rowan.edu.
Rowan University · US

Funding

Translational Rescue Mechanisms in EukaryotesR01GM114308 · NIGMS · ROWAN UNIVERSITY SCHOOL/OSTEOPATHIC MED · PI SHCHERBIK, NATALIA · 2016 to 2020
$1.6M
NIGMS NIH HHS R01 GM114308
6 · The paper itself

Abstract

Stress-induced strand breaks in rRNA have been observed in many organisms, but the mechanisms by which they originate are not well-understood. Here we show that a chemical rather than an enzymatic mechanism initiates rRNA cleavages during oxidative stress in yeast (

Indexed as

Oxidative StressDose-Response Relationship, DrugGlutaredoxinsHydrolysisIronOxidantsReactive Oxygen SpeciesRibosomesRNA, FungalRNA, RibosomalSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsGlutaredoxinsGrx5 protein, S cerevisiaeIronOxidantsReactive Oxygen SpeciesRNA, FungalRNA, RibosomalSaccharomyces cerevisiae Proteinscell deathFenton reactionglutaredoxinironiron homeostasisiron metabolismoxidative stressreactive oxygen species (ROS)ribosomeRNARNA degradationyeast

Identifiers

PMID30021840
PMCPMC6139556
OpenAlexW2884499324

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.