Evidence map›Paper›PMID 30021838›Full record

ArticleThe Journal of biological chemistry2018

Regulation of monoamine oxidase A (MAO-A) expression, activity, and function in IL-13-stimulated monocytes and A549 lung carcinoma cells.

Sukhamoy Dhabal, Pradip Das, Pritam Biswas, Priyanka Kumari, Valentin P Yakubenko, Suman Kundu, Martha K Cathcart, Manjari Kundu, Kaushik Biswas, Ashish Bhattacharjee

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Review
  3. Type A monoamine oxidase; its unique role in mood, behavior and neurodegeneration.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Sukhamoy DhabalFrom the Department of Biotechnology, National Institute of Technology-Durgapur, Mahatma Gandhi Avenue, Durgapur-713209, Burdwan, West Bengal, India.
Pradip DasFrom the Department of Biotechnology, National Institute of Technology-Durgapur, Mahatma Gandhi Avenue, Durgapur-713209, Burdwan, West Bengal, India.
Pritam BiswasFrom the Department of Biotechnology, National Institute of Technology-Durgapur, Mahatma Gandhi Avenue, Durgapur-713209, Burdwan, West Bengal, India.
Priyanka KumariFrom the Department of Biotechnology, National Institute of Technology-Durgapur, Mahatma Gandhi Avenue, Durgapur-713209, Burdwan, West Bengal, India.
Valentin P Yakubenkothe Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, and Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio 44195, and.
Suman Kunduthe Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, and Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio 44195, and.
Martha K Cathcartthe Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, and Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio 44195, and.
Manjari Kunduthe Division of Molecular Medicine, Bose Institute, Kolkata 700054, West Bengal, India.
Kaushik Biswasthe Division of Molecular Medicine, Bose Institute, Kolkata 700054, West Bengal, India.ORCID 0000-0003-2502-9515
Ashish BhattacharjeeFrom the Department of Biotechnology, National Institute of Technology-Durgapur, Mahatma Gandhi Avenue, Durgapur-713209, Burdwan, West Bengal, India, ashish15lo@yahoo.com.
National Institute of Technology Durgapur · INBose Institute · INCleveland Clinic Lerner College of Medicine · USCase Western Reserve University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monoamine oxidase A (MAO-A) is a mitochondrial flavoenzyme implicated in the pathogenesis of atherosclerosis and inflammation and also in many neurological disorders. MAO-A also has been reported as a potential therapeutic target in prostate cancer. However, the regulatory mechanisms controlling cytokine-induced MAO-A expression in immune or cancer cells remain to be identified. Here, we show that MAO-A expression is co-induced with 15-lipoxygenase (15-LO) in interleukin 13 (IL-13)-activated primary human monocytes and A549 non-small cell lung carcinoma cells. We present evidence that

Indexed as

A549 CellsArachidonate 15-LipoxygenaseCell Line, TumorCells, CulturedHumansInflammationInterleukin-13Lung NeoplasmsMonoamine OxidaseMonocytesNeoplasm MetastasisPPAR gammaSTAT6 Transcription FactorU937 CellsArachidonate 15-LipoxygenaseInterleukin-13Monoamine OxidasePPAR gammaSTAT6 protein, humanSTAT6 Transcription Factor15-lipoxygenaseA549 lung cancer cellsalternative activationcell migrationcytokinegene expressiongene regulationhuman monocyteinflammationmonoamine oxidase Amonocyteperoxisome proliferator–activated receptorsignal transducer and activator of transcription

Identifiers

PMID30021838
PMCPMC6130935
OpenAlexW2884499015

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.