Evidence map›Paper›PMID 30021823›Full record

ArticleJournal of clinical microbiology2018

Bronchoalveolar Lavage Fluid Cytology in Culture-Documented Invasive Pulmonary Aspergillosis in Patients with Hematologic Diseases: Analysis of 67 Episodes.

A Fernández-Cruz, E Magira, S T Heo, S Evans, J Tarrand, D P Kontoyiannis

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Journal of clinical microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Current and Future Pathways inAntibiotics (Basel, Switzerland) · 2023
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

A Fernández-CruzDepartment of Infectious Diseases, Infection Control, and Employee Health, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA anafcruz999@gmail.com dkontoyi@mdanderson.org.
E MagiraDepartment of Infectious Diseases, Infection Control, and Employee Health, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
S T HeoDepartment of Infectious Diseases, Infection Control, and Employee Health, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
S EvansDepartment of Pulmonary Medicine, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
J TarrandDepartment of Microbiology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
D P KontoyiannisDepartment of Infectious Diseases, Infection Control, and Employee Health, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA anafcruz999@gmail.com dkontoyi@mdanderson.org.
The University of Texas MD Anderson Cancer Center · USEvangelismos Hospital · GRHospital General Universitario Gregorio Marañón · ESJeju National University · KR

Funding

Epithelial mechanisms of inducible resistance to AML-associated pneumoniaR01HL117976 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI EVANS, SCOTT E. · 2014 to 2018
$2.0M
NHLBI NIH HHS R01 HL117976
6 · The paper itself

Abstract

There is a paucity of studies on the yield of Gomori-methenamine-silver (GMS) staining in bronchoalveolar lavage (BAL) fluid cytology and its comparison with fluorescent dye staining for the diagnosis of invasive pulmonary aspergillosis (IPA) in patients with hematologic malignancies. To that end, we analyzed the yield of direct fungal visualization in BAL fluid cytology with GMS staining, in a series of culture-positive IPA cases in 67 patients with hematologic malignancies, and we compared the results with those of direct examination with calcofluor white staining and BAL fluid galactomannan assays, when available. GMS staining in BAL fluid cytology was positive in 42% of the 67 cases and revealed coinfections in 7 cases. In contrast, only 2/67 (3.6%) BAL fluid samples were positive in direct smears stained with the fluorescent dye calcofluor white. Positive GMS staining results were significantly more frequent in IPA cases with cavitary lesions and IPA cases caused by >1

Indexed as

AdultAspergillusBronchoalveolar Lavage FluidFluorescent DyesHematologic NeoplasmsHumansInvasive Pulmonary AspergillosisMethenamineRetrospective StudiesSensitivity and SpecificityStaining and LabelingFluorescent DyesMethenamineGMShematologic malignancyinvasive aspergillosis

Identifiers

PMID30021823
PMCPMC6156316
OpenAlexW2883998301

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.