ArticleJournal of the American Heart Association2018
Reversal of Aging-Induced Increases in Aortic Stiffness by Targeting Cytoskeletal Protein-Protein Interfaces.
Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Integrin αScientific reports · 2026Article
- The role of aging on endothelial cell-cell junctions and pulmonary microvascular permeability in male mice.Physiological reports · 2025Article
- Pharmacological activation of NO-sensitive guanylyl cyclase ameliorates obesity-induced arterial stiffness.Vascular pharmacology · 2025Article
- PAI-1 Regulates the Cytoskeleton and Intrinsic Stiffness of Vascular Smooth Muscle Cells.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- How vascular smooth muscle cell phenotype switching contributes to vascular disease.Cell communication and signaling : CCS · 2022Review
- Extracellular Matrix in Aging Aorta.Frontiers in cell and developmental biology · 2022Review
- Dynamic Crosstalk between Vascular Smooth Muscle Cells and the Aged Extracellular Matrix.International journal of molecular sciences · 2021Review
- Aging-induced microbleeds of the mouse thalamus compared to sensorimotor and memory defects.Neurobiology of aging · 2021Article
- Non-muscle myosin II regulates aortic stiffness through effects on specific focal adhesion proteins and the non-muscle cortical cytoskeleton.Journal of cellular and molecular medicine · 2021Article
- Vascular aging, the vascular cytoskeleton and aortic stiffness.Exploration of medicine · 2021Article
- Aortic Stiffness: Epidemiology, Risk Factors, and Relevant Biomarkers.Frontiers in cardiovascular medicine · 2021Review
- Large artery stiffness and brain health: insights from animal models.American journal of physiology. Heart and circulatory physiology · 2021Review
- The brains of aged mice are characterized by altered tissue diffusion properties and cerebral microbleeds.Journal of translational medicine · 2020Article
- Aortic Stiffness and Infarct Healing in Survivors of Acute ST-Segment-Elevation Myocardial Infarction.Journal of the American Heart Association · 2020Observational
- Common Carotid Artery Calcification Impacts on Cognitive Function in Older Patients.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2019Article
- Aortic stiffness, pressure and flow pulsatility, and target organ damage.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Review
- Reversal of Aging-Induced Increases in Aortic Stiffness by Targeting Cytoskeletal Protein-Protein Interfaces.Journal of the American Heart Association · 2018Article
- Effect of Acute Resistance Exercise and Resistance Exercise Training on Central Pulsatile Hemodynamics and Large Artery Stiffness: Part II.Pulse (Basel, Switzerland)Article
Corrections and comments
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Authors and funding
12 authors at 20 institutions in 12 countries.
Funding
Abstract
backgroundThe proximal aorta normally functions as a critical shock absorber that protects small downstream vessels from damage by pressure and flow pulsatility generated by the heart during systole. This shock absorber function is impaired with age because of aortic stiffening. METHODS AND
resultsWe examined the contribution of common genetic variation to aortic stiffness in humans by interrogating results from the AortaGen Consortium genome-wide association study of carotid-femoral pulse wave velocity. Common genetic variation in the N-WASP (
conclusionsWe conclude that decoy peptides targeted to vascular smooth muscle cytoskeletal protein-protein interfaces and microbubble packaged can decrease aortic stiffness ex vivo. Our results provide proof of concept at the ex vivo level that decoy peptides targeted to cytoskeletal protein-protein interfaces may lead to substantive dynamic modulation of aortic stiffness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.