Evidence map›Paper›PMID 30021793›Full record

ArticleGenetics2018

Genomic Prediction Using Individual-Level Data and Summary Statistics from Multiple Populations.

Jeremie Vandenplas, Mario P L Calus, Gregor Gorjanc

Abstract read
In one paragraph

Article in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jeremie VandenplasWageningen University and Research, Animal Breeding and Genomics, 6700 AH, The Netherlands jeremie.vandenplas@wur.nl.ORCID 0000-0002-2554-072X
Mario P L CalusWageningen University and Research, Animal Breeding and Genomics, 6700 AH, The Netherlands.ORCID 0000-0002-3213-704X
Gregor GorjancThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Research Centre, Midlothian EH25 9RG, UK.ORCID 0000-0001-8008-2787

Funding

Biotechnology and Biological Sciences Research Council BBS/E/D/30002275
6 · The paper itself

Abstract

This study presents a method for genomic prediction that uses individual-level data and summary statistics from multiple populations. Genome-wide markers are nowadays widely used to predict complex traits, and genomic prediction using multi-population data are an appealing approach to achieve higher prediction accuracies. However, sharing of individual-level data across populations is not always possible. We present a method that enables integration of summary statistics from separate analyses with the available individual-level data. The data can either consist of individuals with single or multiple (weighted) phenotype records per individual. We developed a method based on a hypothetical joint analysis model and absorption of population-specific information. We show that population-specific information is fully captured by estimated allele substitution effects and the accuracy of those estimates,

Indexed as

AllelesAnimalsComputer SimulationData Interpretation, StatisticalForecastingGene FrequencyGenetics, PopulationGenome-Wide Association StudyGenomicsGenotypeHumansModels, GeneticPhenotypeQuantitative Trait LociGenomic PredictionGenPredmeta-analysisquantitative traitShared Data Resourcesstatistical method

Identifiers

PMID30021793
PMCPMC6116972

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.