ArticleBMJ open2018
Keloid risk in patients with atopic dermatitis: a nationwide retrospective cohort study in Taiwan.
Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Systemic Comorbidities of Keloid and Hypertrophic Scars: A Phenome-Wide Association Study in a Multiethnic U.S. Pediatric Cohort.American journal of clinical dermatology · 2026Article
- Regulatory role of POSTN in keloid pathogenesis.Molecular medicine reports · 2025Article
- Association of Keloid with Body Mass Index and Hypertension: A Retrospective Controlled Study.Aesthetic plastic surgery · 2025Article
- Relative risk of keloids in patients with chronic inflammatory skin disorders.JAAD international · 2025Article
- LangerinClinical, cosmetic and investigational dermatology · 2025Review
- Wound Infection After Keloid Excision and Adjuvant Radiotherapy: Two Case Reports and Literature Review.Clinical, cosmetic and investigational dermatology · 2025Article
- Keloids and inflammation: the crucial role of IL-33 in epidermal changes.Frontiers in immunology · 2025Article
- Comprehensive Insights into Keloid Pathogenesis and Advanced Therapeutic Strategies.International journal of molecular sciences · 2024Review
- Revisiting roles of mast cells and neural cells in keloid: exploring their connection to disease activity.Frontiers in immunology · 2024Article
- Identification and validation of CCR5 linking keloid with atopic dermatitis through comprehensive bioinformatics analysis and machine learning.Frontiers in immunology · 2024Article
- The Communication from Immune Cells to the Fibroblasts in Keloids: Implications for Immunotherapy.International journal of molecular sciences · 2023Review
- Keloid Disorder: Genetic Basis, Gene Expression Profiles, and Immunological Modulation of the Fibrotic Processes in the Skin.Cold Spring Harbor perspectives in biology · 2023Review
- Atopic dermatitis is associated with an increased risk of keloids: A case-control study.Journal of the American Academy of Dermatology · 2023Article
- Hypertrophic Scars and Keloids: Advances in Treatment and Review of Established Therapies.American journal of clinical dermatology · 2023Review
- An updated review of the immunological mechanisms of keloid scars.Frontiers in immunology · 2023Review
- Chronic itch in African Americans: an unmet need.Archives of dermatological research · 2022Review
- Migraines and keloids: a 15-year Taiwan claim database analysis.Postgraduate medical journal · 2022Article
- A Signature of Genes FeaturingEmergency medicine international · 2022Article
- The increased prevalence of keloids in atopic dermatitis patients with allergic comorbidities: a nationwide retrospective cohort study.Scientific reports · 2021Article
- Pruritus in Keloid Scars: Mechanisms and Treatments.Acta dermato-venereologica · 2021Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe pathogenesis of keloid is largely unknown. Because keloid and atopic dermatitis have overlapping pathophysiological mechanisms, we aimed to evaluate keloid risk in patients with atopic dermatitis. STUDY
designPopulation-based retrospective cohort study.
settingThe Taiwan National Health Insurance Research Database was used to analyse data for people who had been diagnosed with atopic dermatitis.
participantsWe identified 8371 patients with newly diagnosed atopic dermatitis during 1996-2010. An additional 33 484 controls without atopic dermatitis were randomly identified and frequency matched at a one-to-four ratio. PRIMARY AND SECONDARY OUTCOME MEASURE: The association between atopic dermatitis and keloid risk was estimated using Cox proportional hazard regression models.
resultsAfter adjustment for covariates, the atopic dermatitis patients have a 3.19-fold greater risk of developing keloid compared with the non-atopic dermatitis group (3.19vs1.07 per 1000 person-years, respectively). During the study period, 163 patients with atopic dermatitis and 532 patients without atopic dermatitis developed keloid. Notably, keloid risk increased with severity of atopic dermatitis, particularly in patients with moderate to severe atopic dermatitis.
conclusionsOur results indicate that patients with atopic dermatitis had a higher than normal risk of developing keloid and suggest that atopic dermatitis may be an independent risk factor for keloid.
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