ArticleAlzheimer's research & therapy2018
Single-word comprehension deficits in the nonfluent variant of primary progressive aphasia.
Article in Alzheimer's research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Impaired semantic control in the logopenic variant of primary progressive aphasia.Brain communications · 2025Article
- Primary Progressive Aphasia in Italian and English: A Cross-Linguistic Cohort Study.Neurology · 2024Observational
- Primary progressive aphasia: six questions in search of an answer.Journal of neurology · 2024Review
- Executive Profile of the Logopenic Variant of Primary Progressive Aphasia: Comparison with the Semantic and Non-Fluent Variants and Alzheimer's Disease.Brain sciences · 2023Article
- Word Picture Verification Performance Reveals Auditory Comprehension Deficits in Primary Progressive Aphasia.Journal of neurolinguistics · 2023Article
- Thalamic pathology in frontotemporal dementia: Predilection for specific nuclei, phenotype-specific signatures, clinical correlates, and practical relevance.Brain and behavior · 2023Review
- Left Frontal White Matter Links to Rhythm Processing Relevant to Speech Production in Apraxia of Speech.Neurobiology of language (Cambridge, Mass.) · 2022Article
- Clinical and neuroimaging characteristics of primary progressive aphasia.Handbook of clinical neurology · 2022Review
- Clinical validity of increased cortical binding of tau ligands of the THK family and PBB3 on PET as biomarkers for Alzheimer's disease in the context of a structured 5-phase development framework.European journal of nuclear medicine and molecular imaging · 2021Review
- Primary Progressive Aphasia: Toward a Pathophysiological Synthesis.Current neurology and neuroscience reports · 2021Review
- Classification of primary progressive aphasia: challenges and complexities.F1000Research · 2020Review
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16 authors.
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Abstract
backgroundA subset of patients with the nonfluent variant of primary progressive aphasia (PPA) exhibit concomitant single-word comprehension problems, constituting a 'mixed variant' phenotype. This phenotype is rare and currently not fully characterized. The aim of this study was twofold: to assess the prevalence and nature of single-word comprehension problems in the nonfluent variant and to study multimodal imaging characteristics of atrophy, tau, and amyloid burden associated with this mixed phenotype.
methodsA consecutive memory-clinic recruited series of 20 PPA patients (12 nonfluent, five semantic, and three logopenic variants) were studied on neurolinguistic and neuropsychological domains relative to 64 cognitively intact healthy older control subjects. The neuroimaging battery included high-resolution volumetric magnetic resonance imaging processed with voxel-based morphometry, and positron emission tomography with the tau-tracer [
resultsSeven out of 12 subjects who had been classified a priori with nonfluent variant PPA showed deficits on conventional single-word comprehension tasks along with speech apraxia and agrammatism, corresponding to a mixed variant phenotype. These mixed variant cases included three females and four males, with a mean age at onset of 65 years (range 44-77 years). Object knowledge and object recognition were additionally affected, although less severely compared with the semantic variant. The mixed variant was characterized by a distributed atrophy pattern in frontal and temporoparietal regions. A more focal pattern of elevated [
conclusionsA substantial proportion of PPA patients with speech apraxia and agrammatism also have single-word comprehension deficits. At the neurobiological level, the mixed variant shows a high degree of similarity with the pure nonfluent variant of PPA.
trial registrationEudraCT, 2014-002976-10 . Registered on 13-01-2015.
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