Observational studyPediatric rheumatology online journal2018
Kawasaki disease: abnormal initial echocardiogram is associated with resistance to IV Ig and development of coronary artery lesions.
Observational study in Pediatric rheumatology online journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Pooled it
- Low platelet count, immunoglobulin resistance, and coronary artery involvement in Kawasaki disease.Pediatric research · 2026Article
- Coronary inflammatory imaging and clinical factors: associations with coronary artery aneurysm regression in pediatric Kawasaki disease.The international journal of cardiovascular imaging · 2026Article
- Multimodal Echocardiographic Assessment in Intravenous Immunoglobulin-Resistant Kawasaki Disease: From Prediction to Long-Term Surveillance.Echocardiography (Mount Kisco, N.Y.) · 2026Review
- Gastrointestinal abnormalities as predictors of cardiovascular involvement in Kawasaki disease: a 5-year retrospective study.BMC pediatrics · 2026Article
- A machine learning-based model to predict intravenous immunoglobulin resistance in Kawasaki disease.iScience · 2025Article
- The predictive value of urinary albumin-to-creatinine ratio for coronary artery abnormalities in Kawasaki disease.Frontiers in pediatrics · 2025Article
- Prediction nomogram for coronary artery aneurysms at one month in Kawasaki disease.Italian journal of pediatrics · 2023Article
- Intravenous Immunoglobulin in Kawasaki Disease-Evolution and Pathogenic Mechanisms.Diagnostics (Basel, Switzerland) · 2023Review
- Evaluation of Formosa score and diagnostic sensitivity and specificity of four Asian risk scores for predicting intravenous immunoglobulin resistance in Kawasaki disease: a bivariate meta-analysis.Frontiers in cardiovascular medicine · 2023Review
- Development of a score for early identification of children with Kawasaki disease requiring second-line treatment in multi-ethnic populations in Europe: A multicentre retrospective cohort study.The Lancet regional health. Europe · 2022Article
- Albumin level and progression of coronary artery lesions in Kawasaki disease: A retrospective cohort study.Frontiers in pediatrics · 2022Article
- Kawasaki Disease With Coronary Artery Lesions Detected at Initial Echocardiography.Journal of the American Heart Association · 2021Article
- Kawasaki Disease: Predictors of Resistance to Intravenous Immunoglobulin and Cardiac Complications.Arquivos brasileiros de cardiologia · 2021Article
- A Retrospective Cohort Study of Intravenous Immunoglobulin Therapy in the Acute Phase of Kawasaki Disease: The Earlier, the Better?Cardiovascular therapeutics · 2021Article
- Prediction of Coronary Artery Aneurysms in Children With Kawasaki Disease Before Starting Initial Treatment.Frontiers in pediatrics · 2021Article
- Prognosis and Risk Factors of Coronary Artery Lesions before Immunoglobulin Therapy in Children with Kawasaki DiseaseBalkan medical journal · 2020Article
- Emergence of Kawasaki disease related to SARS-CoV-2 infection in an epicentre of the French COVID-19 epidemic: a time-series analysis.The Lancet. Child & adolescent health · 2020Article
- Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort.Annals of the rheumatic diseases · 2020Article
- Predictors and management of intravenous immunoglobulin-resistant Kawasaki disease.Korean journal of pediatrics · 2019Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKawasaki disease (KD) is an acute febrile systemic vasculitis that affects small and medium blood vessels. Intensified treatments for the most severely affected patients have been proposed recently, and the early identification of KD patients at high risk for coronary artery aneurysms (CAA) is crucial. However, the risk scoring systems developed in Japan have not been validated in European populations, and little data is available concerning the link between initial echocardiogram findings other than high z-scores and cardiac prognosis.
methodsIn order to investigate whether the presence of any abnormalities, other than high z-scores in first echocardiogram, are associated with resistance to IV immunoglobulins and/or subsequent development of CAA, we retrospectively analyzed data from children diagnosed with KD between 2006 and 2016 at a tertiary Hospital in Paris, France.
resultsA total of 157 children were included. The initial echocardiogram was performed after a median of 7 days of fever and was abnormal in 48 cases (31%). The initial presence of any echocardiographic abnormality (coronary artery dilatation, CAA, pericardial effusion, perivascular brightness of the coronary arteries, left-ventricular dysfunction and mitral insufficiency) was strongly associated with resistance to intravenous immunoglobulin (p = 0.005) and development of coronary artery lesions within the first 6 weeks of disease (p = 0.01). All patients (n = 7) with persistent coronary abnormalities at 1 year already had an abnormal initial echocardiogram. Severity scoring systems from Japan had low sensitivity (0-33%) and low specificity (71-82%) for predicting immunoglobulin resistance or cardiac involvement.
conclusionsIn European populations with mixed ethnic backgrounds, the presence of any abnormalities at the initial echocardiogram may contribute to early identification of patients with severe disease.
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