ArticleLipids in health and disease2018
Western diet feeding influences gut microbiota profiles in apoE knockout mice.
Article in Lipids in health and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- The Western Diet and Atopic Dermatitis: The Potential Role of Nutrients, Contaminants, and Additives in Dysbiosis and Epithelial Barrier Dysfunction.Antioxidants (Basel, Switzerland) · 2025Review
- Electroacupuncture Improves Myocardial Fibrosis in Association With Intestinal Flora and Metabolic Modulation in Mice.Cardiology research and practice · 2025Article
- Unveiling the oral-gut connection: chronic apical periodontitis accelerates atherosclerosis via gut microbiota dysbiosis and altered metabolites in apoEInternational journal of oral science · 2024Article
- Dietary Factors and the Risk of Depression among Women with Polycystic Ovary Syndrome.Nutrients · 2024Article
- Changes in gut microbiota after gastric cancer surgery: a prospective longitudinal study.Frontiers in oncology · 2024Article
- From-Toilet-to-Freezer: A Review on Requirements for an Automatic Protocol to Collect and Store Human Fecal Samples for Research Purposes.Biomedicines · 2023Review
- Inhibition of MAOB Ameliorated High-Fat-Diet-Induced Atherosclerosis by Inhibiting Endothelial Dysfunction and Modulating Gut Microbiota.Nutrients · 2023Article
- Physical Exercise and Diet: Regulation of Gut Microbiota to Prevent and Treat Metabolic Disorders to Maintain Health.Nutrients · 2023Review
- Gut microbiota mediate vascular dysfunction in a murine model of sleep apnoea: effect of probiotics.The European respiratory journal · 2023Article
- Effects of prebiotics on the gut microbiotaFrontiers in microbiology · 2023Article
- Modulation of Intestinal Flora by Dietary Polysaccharides: A Novel Approach for the Treatment and Prevention of Metabolic Disorders.Foods (Basel, Switzerland) · 2022Review
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- Endurance exercise ameliorates Western diet-induced atherosclerosis through modulation of microbiota and its metabolites.Scientific reports · 2022Article
- Natural products against inflammation and atherosclerosis: Targeting on gut microbiota.Frontiers in microbiology · 2022Review
- Circulating gut microbiota-related metabolites influence endothelium plaque lesion formation in ApoE knockout rats.PloS one · 2022Article
- Beneficial Effects of a Low-Glycemic Diet on Serum Metabolites and Gut Microbiota in Obese Women WithFrontiers in nutrition · 2022Article
- Intermittent fasting positively modulates human gut microbial diversity and ameliorates blood lipid profile.Frontiers in microbiology · 2022Article
- Interactions between parasitic helminths and gut microbiota in wild tropical primates from intact and fragmented habitats.Scientific reports · 2021Article
- Impaired skeletal muscle hypertrophy signaling and amino acid deprivation response in Apoe knockout mice with an unhealthy lipoprotein distribution.Scientific reports · 2021Article
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10 authors.
Funding
Abstract
backgroundGut microbiota plays an important role in many metabolic diseases such as diabetes and atherosclerosis. Apolipoprotein E (apoE) knock-out (KO) mice are frequently used for the study of hyperlipidemia and atherosclerosis. However, it is unknown whether apoE KO mice have altered gut microbiota when challenged with a Western diet.
methodsIn the current study, we assessed the gut microbiota profiling of apoE KO mice and compared with wild-type mice fed either a normal chow or Western diet for 12 weeks using 16S pyrosequencing.
resultsOn a western diet, the gut microbiota diversity was significantly decreased in apoE KO mice compared with wild type (WT) mice. Firmicutes and Erysipelotrichaceae were significantly increased in WT mice but Erysipelotrichaceae was unchanged in apoE KO mice on a Western diet. The weighted UniFrac principal coordinate analysis exhibited clear separation between WT and apoE KO mice on the first vector (58.6%) with significant changes of two dominant phyla (Bacteroidetes and Firmicutes) and seven dominant families (Porphyromonadaceae, Lachnospiraceae, Ruminococcaceae, Desulfovibrionaceae, Helicobacteraceae, Erysipelotrichaceae and Veillonellaceae). Lachnospiraceae was significantly enriched in apoE KO mice on a Western diet. In addition, Lachnospiraceae and Ruminococcaceae were positively correlated with relative atherosclerosis lesion size in apoE KO.
conclusionsCollectively, our study showed that there are marked changes in the gut microbiota of apoE KO mice, particularly challenged with a Western diet and these alterations may be possibly associated with atherosclerosis.
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