ArticleBMC musculoskeletal disorders2018
Age-dependent bone loss and recovery during hindlimb unloading and subsequent reloading in rats.
Article in BMC musculoskeletal disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Effects of resistance exercise in prostate cancer patients : A systematic review update as of March 2020.Wiener klinische Wochenschrift · 2020Pooled it
- Age-dependent musculoskeletal changes during mechanical unloading with bisphosphonate treatment.Bone · 2026Article
- A mathematical model of osteocyte network control of bone mechanical adaptation.Biomechanics and modeling in mechanobiology · 2026Article
- Changes in bone metabolism dynamics in response to mechanical stress under pulmonary emphysema.Journal of bone and mineral metabolism · 2026Article
- Hindlimb Suspension and Subsequent Weight-Loading on Femoral Morphology, Knee Joint Alignment, and Patellar Tracking in Growing Rats.Journal of musculoskeletal & neuronal interactions · 2025Article
- Advancements in High-Resolution Computed Tomography: Revolutionising Bone Health Micro-Research.Bioengineering (Basel, Switzerland) · 2025Article
- Toward a clear relationship between mechanical signals and bone adaptation.Mechanobiology in medicine · 2025Review
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- A Mini Review on Osteoporosis: From Biology to Pharmacological Management of Bone Loss.Journal of clinical medicine · 2022Review
- Similarities Between Disuse and Age-Induced Bone Loss.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Review
- Bone strength and composition in spacefaring rodents: systematic review and meta-analysis.NPJ microgravity · 2022Article
- Regulation of bone health through physical exercise: Mechanisms and types.Frontiers in endocrinology · 2022Review
- Bone health in spacefaring rodents and primates: systematic review and meta-analysis.NPJ microgravity · 2021Article
- The Role of Long-Term Head-Down Bed Rest in Understanding Inter-Individual Variation in Response to the Spaceflight Environment: A Perspective Review.Frontiers in physiology · 2021Article
- The Potential Mechanism of Exercise Combined with Natural Extracts to Prevent and Treat Postmenopausal Osteoporosis.Journal of healthcare engineering · 2021Review
- The Role of Irisin in Exercise-Mediated Bone Health.Frontiers in cell and developmental biology · 2021Review
- RNAseq and RNA molecular barcoding reveal differential gene expression in cortical bone following hindlimb unloading in female mice.PloS one · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundBone structure and strength are rapidly lost during conditions of decreased mechanical loading, and aged bones have a diminished ability to adapt to increased mechanical loading. This is a concern for older patients that experience periods of limited mobility or bed rest, but the acute effects of disuse on the bones of aged patients have not been thoroughly described. Previous animal studies have primarily examined the effect of mechanical unloading on young animals. Those that have studied aged animals have exclusively focused on bone loss during unloading and not bone recovery during subsequent reloading. In this study, we investigated the effect of decreased mechanical loading and subsequent reloading on bone using a hindlimb unloading model in Adult (9 month old) and Aged (28 month old) male rats.
methodsAnimals from both age groups were subjected to 14 days of hindlimb unloading followed by up to 7 days of reloading. Additional Aged rats were subjected to 7 days of forced treadmill exercise during reloading or a total of 28 days of reloading. Trabecular and cortical bone structure of the femur were quantified using ex vivo micro-computed tomography (μCT), and mechanical properties were quantified with mechanical testing.
resultsWe found that Adult rats had substantially decreased trabecular bone volume fraction (BV/TV) following unloading (- 27%) while Aged animals did not exhibit significant bone loss following unloading. However, Aged animals had lower trabecular BV/TV after 3 days of reloading (- 20% compared to baseline), while trabecular BV/TV of Adult rats was not different from baseline values after 3 days of reloading. Trabecular BV/TV of Aged animals remained lower than control animals even with exercise during 7 days of reloading and after 28 days of reloading.
conclusionsThese data suggest that aged bone is less responsive to both increased and decreased mechanical loading, and that acute periods of disuse may leave older subjects with a long-term deficit in trabecular bone mass. These finding indicate the need for therapeutic strategies to improve the skeletal health of elderly patients during periods of disuse.
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