Evidence map›Paper›PMID 30021580›Full record

Trial reportBMC pediatrics2018

Early versus delayed cord clamping in small for gestational age infants and iron stores at 3 months of age - a randomized controlled trial.

Abhishek Chopra, Anup Thakur, Pankaj Garg, Neelam Kler, Kanwal Gujral

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04358822 (Hemodynamic Effects of Delayed Umbilical Cord Clamping in Full-term Newborns), which is not on this map. Cited by 15 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 5 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04358822 nacompletednot on this mapstarted 2020, after this paper: background citation

Hemodynamic Effects of Delayed Umbilical Cord Clamping in Full-term Newborns

TypeinterventionalSponsorCairo UniversityRan2020 to 2020Enrolled68ConditionsCardiac Output, High, Cardiac Output, LowArmsDelayed cord clamping
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 5 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Guideline
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Care of the Newborn and Cord During the Third Stage of Labour (Scientific Impact Paper No. 78).BJOG : an international journal of obstetrics and gynaecology · 2026
    Review
  10. How Delayed Cord Clamping Saves Newborn Lives.Children (Basel, Switzerland) · 2025
    Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Abhishek ChopraDepartment of Neonatology, Sir Ganga Ram Hospital, New Delhi, India.
Anup ThakurDepartment of Neonatology, Sir Ganga Ram Hospital, New Delhi, India.
Pankaj GargDepartment of Neonatology, Sir Ganga Ram Hospital, New Delhi, India.
Neelam KlerDepartment of Neonatology, Sir Ganga Ram Hospital, New Delhi, India. drneelamkler@gmail.com.
Kanwal GujralDepartment of Obstetrics and Gynecology, Sir Ganga Ram Hospital, New Delhi, India.
Sir Ganga Ram Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDelayed cord clamping is the standard of care in infants not requiring resuscitation; however effects of cord clamping strategies have not been evaluated systematically in small for gestational age (SGA) infants. The primary objective was to compare effects of delayed cord clamping (DCC) and early cord clamping (ECC) on serum ferritin at 3 months in SGA infants born at ≥35 weeks. The secondary objectives were to compare hematological parameters, clinical outcomes in neonatal period and growth at 3 months of age.

methodsAll eligible infants with fetal growth restriction were randomized to two groups, DCC at 60 s or ECC group in which the cord was clamped immediately after birth.

resultsTotal of 142 infants underwent randomization and subsequently 113 infants underwent definite inclusion. At 3 months, the median (IQR) serum ferritin levels were higher in DCC group, compared to ECC; 86 ng/ml (43.35-134.75) vs 50.5 ng/ml (29.5-83.5), p = 0.01. Fewer infants had iron deficiency in DCC group compared to ECC group; 9 (23.6%) vs 21 (47.7%), p = 0.03 [NNT being 4; 95% CI (2-25)].The proportion of infants with polycythemia was significantly higher in DCC group; 23 (41.81) % vs 12 (20.6%), p = 0.01. There was no difference in proportion of infants with symptomatic polycythemia or those who underwent partial exchange transfusions. Clinical outcomes and mortality were similar.

conclusionsDCC improves iron stores in SGA infants ≥35 weeks at 3 months of age without increasing the risk of symptomatic polycythemia, need for partial exchange transfusions or morbidities associated with polycythemia.

trial registrationOur trial was retrospectively registered on 29th May 2015 through Clinical trials registry India. Registration number: CTRI 2015/05/005828 .

Indexed as

Umbilical CordAnemia, Iron-DeficiencyConstrictionDelivery, ObstetricExchange Transfusion, Whole BloodFemaleFerritinsHematocritHemoglobinsHumansHyperbilirubinemiaIndiaInfant, NewbornInfant, Small for Gestational AgeMalePolycythemiaFerritinsHemoglobinsDelayed cord clampingEarly cord clampingFerritinHemoglobinPartial exchangePolycythemiaSmall for gestational age

Identifiers

PMID30021580
PMCPMC6052555
OpenAlexW2884442178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.