ArticleBMC anesthesiology2018
Evaluation of a combination "lymphocyte apoptosis model" to predict survival of sepsis patients in an intensive care unit.
Article in BMC anesthesiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Cell death in sepsis: unveiling new perspectives on organ dysfunction.Frontiers in cell and developmental biology · 2026Review
- Circulating Toll-like receptor and cytokine profiles and genetic polymorphisms in a Chinese sepsis cohort: potential links to neuroinflammation and blood-brain barrier dysfunction.Frontiers in immunology · 2026Article
- Predictive value of PD-1Scientific reports · 2025Article
- Constructing an early warning model for elderly sepsis patients based on machine learning.Scientific reports · 2025Article
- Exosomal Drug Delivery Systems: A Novel Therapy Targeting PD-1 in Septic-ALI.Stem cell reviews and reports · 2024Article
- The neutrophil-to-lymphocyte ratio levels over time correlate to all-cause hospital mortality in sepsis.Heliyon · 2024Article
- U-shaped correlation of lymphocyte count with all-cause hospital mortality in sepsis and septic shock patients: a MIMIC-IV and eICU-CRD database study.International journal of emergency medicine · 2024Article
- Clinical predictive value of the CRP-albumin-lymphocyte index for prognosis of critically ill patients with sepsis in intensive care unit: a retrospective single-center observational study.Frontiers in public health · 2024Observational
- miR-21 Regulates Immune Balance Mediated by Th17/Treg in Peripheral Blood of Septic Rats during the Early Phase through Apoptosis Pathway.Biochemistry research international · 2022Article
- ICU and Sepsis: Role of Myeloid and Lymphocyte Immune Cells.Journal of oncology · 2022Review
- Immunomonitoring of Monocyte and Neutrophil Function in Critically Ill Patients: From Sepsis and/or Trauma to COVID-19.Journal of clinical medicine · 2021Review
- LncRNA HOTAIR Promotes LPS-Induced Inflammation and Apoptosis of Cardiomyocytes via Lin28-Mediated PDCD4 Stability.Inflammation · 2021Article
- Human Leukocyte Antigen-DR Isotype Expression in Monocytes and T Cells Interferon-Gamma Release Assay in Septic Patients and Correlation With Clinical Outcome.Journal of clinical medicine research · 2021Article
- Survivin and caspases serum protein levels and survivin variants mRNA expression in sepsis.Scientific reports · 2021Observational
- Survival prediction of patients with sepsis from age, sex, and septic episode number alone.Scientific reports · 2020Article
- Long non-coding RNA-HOTAIR promotes the progression of sepsis by acting as a sponge of miR-211 to induce IL-6R expression.Experimental and therapeutic medicine · 2019Article
- A new indicator: The diagnostic value of CD8+T/B lymphocyte ratio in sepsis progression.International journal of immunopathology and pharmacologyArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA major challenge in sepsis intervention is unclear risk stratification. We postulated that a panel of biomarkers of lymphocyte apoptosis and immune function, termed the "lymphocyte apoptosis model," would be an effective tool for predicting 28-day survival for sepsis patients.
methodsA total of 52 consecutive sepsis patients were enrolled. Peripheral blood samples were collected on day 1 of admission for quantification of biomarkers of lymphocyte apoptosis and immune function, including lymphocyte count, lymphocyte apoptotic percentage, expression on monocyte HLA-DR, CD4
resultsCompared with survivors, non-survivors had significantly higher lymphocyte apoptotic percentages and plasma cytochrome c levels and significantly lower lymphocyte counts, Th1/Th2 ratios, and HLA-DR expression on day 1 of admission. Multivariate analysis identified cytochrome c levels (odds ratio [OR]1.829, p = 0.025), lymphocyte apoptotic percentage (OR 1.103, p = 0.028), lymphocyte count (OR 0.150, p = 0.047), and HLA-DR expression (OR 0.923, p = 0.021) as independent predictors of 28-day mortality. A logistic regression equation incorporating the independent risk factors predicted 28-day mortality with greater accuracy than did the APACHE II score or single components biomarkers.
conclusionsThe "lymphocyte apoptosis model" may be useful for risk stratification and predicting prognosis of sepsis patients.
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Registered trials
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