Evidence map›Paper›PMID 30021543›Full record

ArticleBMC public health2018

Evaluating the impact of screening plus eave tubes on malaria transmission compared to current best practice in central Côte d'Ivoire: a two armed cluster randomized controlled trial.

Eleanore D Sternberg, Jackie Cook, Ludovic P Ahoua Alou, Carine J Aoura, Serge Brice Assi, Dimi Théodore Doudou, A Alphonsine Koffi, Raphael N'Guessan, Welbeck A Oumbouke, Rachel A Smith and 3 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. House modifications for preventing malaria.The Cochrane database of systematic reviews · 2021
    Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. The role of human and mosquito behaviour in the efficacy of a house-based intervention.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021
    Article
  15. Novel control strategies for mosquito-borne diseases.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 4 countries.

Eleanore D SternbergDepartment of Entomology and Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, 16802, PA, USA. eds16@psu.edu.ORCID 0000-0003-3514-4111
Jackie CookMRC Tropical Epidemiology Group, Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
Ludovic P Ahoua AlouInstitut Pierre Richet (IPR) / Institut National de Santé Publique (INSP), Bouaké, Côte d'Ivoire.
Carine J AouraInstitut Pierre Richet (IPR) / Institut National de Santé Publique (INSP), Bouaké, Côte d'Ivoire.
Serge Brice AssiInstitut Pierre Richet (IPR) / Institut National de Santé Publique (INSP), Bouaké, Côte d'Ivoire.
Dimi Théodore DoudouUniversité Alassane Ouattara, Bouaké, Côte d'Ivoire.
A Alphonsine KoffiInstitut Pierre Richet (IPR) / Institut National de Santé Publique (INSP), Bouaké, Côte d'Ivoire.
Raphael N'GuessanInstitut Pierre Richet (IPR) / Institut National de Santé Publique (INSP), Bouaké, Côte d'Ivoire.
Welbeck A OumboukeInstitut Pierre Richet (IPR) / Institut National de Santé Publique (INSP), Bouaké, Côte d'Ivoire.
Rachel A SmithDepartment of Communication Arts and Sciences and Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, 16802, PA, USA.
Eve WorrallDepartment of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, UK.
Immo KleinschmidtMRC Tropical Epidemiology Group, Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
Matthew B ThomasDepartment of Entomology and Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, 16802, PA, USA.
Institut National de Santé Publique · CIPennsylvania State University · USLondon School of Hygiene & Tropical Medicine · GBLiverpool School of Tropical Medicine · GBUniversité Alassane Ouattara · CIUniversity of the Witwatersrand · ZA

Funding

Medical Research Council MR/K012126/1
6 · The paper itself

Abstract

backgroundAccess to long-lasting insecticidal nets (LLINs) has increased and malaria has decreased globally, but malaria transmission remains high in parts of sub-Saharan Africa and insecticide resistance threatens current progress. Eave tubes are a new tool for the targeted delivery of insecticides against mosquitoes attempting to enter houses. The primary objective of this trial is to test whether screening plus eave tubes (SET) provides protection against malaria, on top of universal coverage with LLINs in an area of intense pyrethroid resistance. The trial will also assess acceptability and cost-effectiveness of the intervention. METHODS/

designA two-armed, cluster randomized controlled trial will be conducted to evaluate the effect of SET on clinical malaria incidence in children living in central Côte d'Ivoire. Forty villages will be selected based on population size and the proportion of houses suitable for modification with SET. Using restricted randomization, half the villages will be assigned to the treatment arm (SET + LLINs) and the remainder will be assigned to the control arm (LLINs only). In both arms, LLINs will be distributed and in the treatment arm, householders will be offered SET. Fifty children aged six months to eight years old will be enrolled from randomly selected households in each of the 40 villages. Cohorts will be cleared of malaria parasites at the start of the study and one year after recruitment, and will be monitored for clinical malaria case incidence by active case detection over two years. Mosquito densities will be assessed using CDC light traps and human landing catches and a subset of Anopheles mosquitoes will be examined for parity status and tested for sporozoite infection. Acceptability of SET will be monitored using surveys and focus groups. Cost-effectiveness analysis will measure the incremental cost per case averted and per disability-adjusted life year (DALY) averted of adding SET to LLINs. Economic and financial costs will be estimated from societal and provider perspective using standard economic evaluation methods. DISCUSSION: This study will be the first evaluation of the epidemiological impact of SET. Trial findings will show whether SET is a viable, cost-effective technology for malaria control in Côte d'Ivoire and possibly elsewhere.

trial registrationISRCTN18145556 , registered on 01 February 2017 - retrospectively registered.

Indexed as

InsecticidesInsecticide-Treated BednetsMalariaMosquito ControlAnemiaAnimalsAnophelesChildChild, PreschoolCost-Benefit AnalysisCote d'IvoireDisease Transmission, InfectiousEndemic DiseasesFemaleHumansIncidenceInsecticidesClinical malariaCost-effectivenessEave tubesEconomic evaluationHouse screeningHousingLLINsMalaria controlScreening plus eave tubesSET

Identifiers

PMID30021543
PMCPMC6052618
OpenAlexW2884996442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.