ArticleJournal of the American Chemical Society2018
Engineering a 3D DNA-Logic Gate Nanomachine for Bispecific Recognition and Computing on Target Cell Surfaces.
Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed.
- Programmable DNA Logic Systems for Applications in Biomedicine.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Fluorescence encoding technology based tetrahedral nano-string for logic identification of breast cancer cells.Materials today. Bio · 2026Article
- A general and scalable DNA nano-chip with a fully localized architecture enables biocomputing in living cells and precisely induces cell apoptosis.Chemical science · 2026Article
- Dynamic Decoration of DNA Scaffolds for High-Resolution Cancer Cell Subtyping.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Multivalent aptamer engineered and functionalized NK cells for enhanced adoptive immunotherapy in CD30-positive malignant lymphoma.Molecular therapy. Nucleic acids · 2025Article
- Review
- Microenvironment-confined kinetic elucidation and implementation of a DNA nano-phage with a shielded internal computing layer.Nature communications · 2025Article
- Nanotechnology-based biomedical devices in the cancer diagnostics and therapy.Medical oncology (Northwood, London, England) · 2025Review
- All-in-one Biocomputing Nanoagents with Multilayered Transformable Architecture based on DNA Interfaces.Theranostics · 2025Article
- Advances in micro-/nanorobots for cancer diagnosis and treatment: propulsion mechanisms, early detection, and cancer therapy.Frontiers in chemistry · 2025Review
- Fluorescence-Based Multimodal DNA Logic Gates.Nanomaterials (Basel, Switzerland) · 2024Article
- Review
- Recent progress in stimuli-responsive DNA-based logic gates: Design, working principles and biological applications.Smart molecules : open access · 2024Review
- DNA Logic Gates for Small Molecule Activation Circuits in Cells.ACS synthetic biology · 2024Article
- A DNA rotary nanodevice operated by enzyme-initiated strand resetting.Chemical communications (Cambridge, England) · 2024Article
- Smart DNA sensors-based molecular identification for cancer subtyping.Smart molecules : open access · 2023Review
- Review
- Advances of medical nanorobots for future cancer treatments.Journal of hematology & oncology · 2023Review
- Isotope-encoded tetrahedral DNA for multiple SARS-CoV-2 variant diagnosis.Chemical science · 2023Article
- PhotocleavableChemical reviews · 2023Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Among the vast number of recognition molecules, DNA aptamers generated from cell-SELEX exhibit unique properties for identifying cell membrane biomarkers, in particular protein receptors on cancer cells. To integrate all recognition and computing modules within a single structure, a three-dimensional (3D) DNA-based logic gate nanomachine was constructed to target overexpressed cancer cell biomarkers with bispecific recognition. Thus, when the Boolean operator "AND" returns a true value, it is followed by an "ON" signal when the specific cell type is presented. Compared with freely dispersed double-stranded DNA (dsDNA)-based molecular circuits, this 3D DNA nanostructure, termed DNA-logic gate triangular prism (TP), showed better identification performance, enabling, in turn, better molecular targeting and fabrication of recognition nanorobotics.
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Registered trials
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