ArticleBiophysical journal2018
Antimargination of Microparticles and Platelets in the Vicinity of Branching Vessels.
Article in Biophysical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 34 citations in OpenAlex.
- Effects of the Mechanical Behaviors of Red Blood Cells on the Blood Flow.Advances in experimental medicine and biology · 2026Article
- Predicting red blood cell transport and capillary hemodynamics in angiogenic and tumor vascular networks in silico.Biophysical journal · 2025Article
- A High-Fidelity Computational Model for Predicting Blood Cell Trafficking and 3D Capillary Hemodynamics in Retinal Microvascular Networks.Investigative ophthalmology & visual science · 2024Article
- The volume of healthy red blood cells is optimal for advective oxygen transport in arterioles.Biophysical journal · 2024Article
- Article
- Marginated aberrant red blood cells induce pathologic vascular stress fluctuations in a computational model of hematologic disorders.Science advances · 2023Article
- Application of machine learning in predicting blood flow and red cell distribution in capillary vessel networks.Journal of the Royal Society, Interface · 2022Article
- Lingering Dynamics in Microvascular Blood Flow.Biophysical journal · 2021Article
- Flow-accelerated platelet biogenesis is due to an elasto-hydrodynamic instability.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- The Evolution of Erythrocytes Becoming Red in Respect to Fluorescence.Frontiers in physiology · 2019Article
- Red Blood Cells: Chasing Interactions.Frontiers in physiology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigate the margination of microparticles/platelets in blood flow through complex geometries typical for in vivo vessel networks: a vessel confluence and a bifurcation. Using three-dimensional lattice Boltzmann simulations, we confirm that behind the confluence of two vessels, a cell-free layer devoid of red blood cells develops in the channel center. Despite its small size of roughly 1 μm, this central cell-free layer persists for up to 100 μm after the confluence. Most importantly, we show from simulations that this layer also contains a significant amount of microparticles/platelets and validate this result by in vivo microscopy in mouse venules. At bifurcations, however, a similar effect does not appear, and margination is largely unaffected by the geometry. This antimargination toward the vessel center after a confluence may explain earlier in vivo observations, which found that platelet concentrations near the vessel wall are seen to be much higher on the arteriolar side (containing bifurcations) than on the venular side (containing confluences) of the vascular system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.