Evidence map›Paper›PMID 30021110›Full record

ArticleBiophysical journal2018

Light-Driven Chloride Transport Kinetics of Halorhodopsin.

Hasin Feroz, Bryan Ferlez, Cecile Lefoulon, Tingwei Ren, Carol S Baker, John P Gajewski, Daniel J Lugar, Sandeep B Gaudana, Peter J Butler, Jonas Hühn and 8 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Optogenetics at the presynapse.Nature neuroscience · 2022
    Review
  4. Functional Mechanism of ClAdvances in experimental medicine and biology · 2021
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 3 countries.

Hasin FerozDepartment of Chemical Engineering, The Pennsylvania State University, University Park, Pennsylvania.
Bryan FerlezDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania.
Cecile LefoulonLaboratory of Plant Physiology and Biophysics, Institute of Molecular Cell and Systems Biology, University of Glasgow, Glasgow, United Kingdom.
Tingwei RenDepartment of Chemical Engineering, The Pennsylvania State University, University Park, Pennsylvania.
Carol S BakerDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania.
John P GajewskiDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania.
Daniel J LugarDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania.
Sandeep B GaudanaMSU-DOE Plant Research Laboratory and Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan.
Peter J ButlerDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania.
Jonas HühnDepartment of Physics and Chemistry, Philipps University of Marburg, Marburg, Germany.
Matthias LampingDepartment of Physics and Chemistry, Philipps University of Marburg, Marburg, Germany.
Wolfgang J ParakDepartment of Physics and Chemistry, Philipps University of Marburg, Marburg, Germany.
Julian M HibberdDepartment of Plant Sciences, University of Cambridge, Cambridge, United Kingdom.
Cheryl A KerfeldMSU-DOE Plant Research Laboratory and Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan; Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, California; Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, California.
Nicholas SmirnoffSchool of Biosciences, University of Exeter, Exeter, United Kingdom.
Michael R BlattLaboratory of Plant Physiology and Biophysics, Institute of Molecular Cell and Systems Biology, University of Glasgow, Glasgow, United Kingdom.
John H GolbeckDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania; Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania.
Manish KumarDepartment of Chemical Engineering, The Pennsylvania State University, University Park, Pennsylvania. Electronic address: manish.kumar@psu.edu.
Pennsylvania State University · USPhilipps University of Marburg · DEUniversity of Glasgow · GBMichigan State University · USUniversity of California, Berkeley · USUniversity of Cambridge · GBUniversity of Exeter · GB

Funding

Biotechnology and Biological Sciences Research Council BB/C500595/1Biotechnology and Biological Sciences Research Council BB/D001528/1Biotechnology and Biological Sciences Research Council BB/F001630/1Biotechnology and Biological Sciences Research Council BB/F001673/1Biotechnology and Biological Sciences Research Council BB/H009817/1Biotechnology and Biological Sciences Research Council BB/M011429/1Biotechnology and Biological Sciences Research Council P12750
6 · The paper itself

Abstract

Despite growing interest in light-driven ion pumps for use in optogenetics, current estimates of their transport rates span two orders of magnitude due to challenges in measuring slow transport processes and determining protein concentration and/or orientation in membranes in vitro. In this study, we report, to our knowledge, the first direct quantitative measurement of light-driven Cl

Indexed as

LightChloridesHalobacteriaceaeHalorhodopsinsIon TransportKineticsChloridesHalorhodopsins

Identifiers

PMID30021110
PMCPMC6051019
OpenAlexW2884963389

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.