ArticlePloS one2018
Skin mucosome activity as an indicator of Batrachochytrium salamandrivorans susceptibility in salamanders.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Animal medical systems from Apis to apes: history, recent advances and future perspectives.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Bsal susceptibility depends on host origin but not on skin microbiota in captive Pleurodeles waltl.Animal microbiome · 2025Article
- Amphibians as a source of bioactive antioxidant peptides: Emerging insights and therapeutic potential.Zoological research · 2025Review
- In Vitro Infection Model Using A6 Cells Sets the Stage for Host-Journal of fungi (Basel, Switzerland) · 2025Article
- Article
- Family shapes microbiome differences in Oklahoma salamanders.Frontiers in microbiomes · 2024Article
- Divergent population responses following salamander mass mortalities and declines driven by the emerging pathogenProceedings. Biological sciences · 2023Article
- Bacterial Skin Assemblages of Sympatric Salamanders Are Primarily Shaped by Host Genus.Microbial ecology · 2023Article
- In Vitro Investigation of the Antibacterial Activity of Salamander Skin Peptides.Current microbiology · 2023Article
- Major Emerging Fungal Diseases of Reptiles and Amphibians.Pathogens (Basel, Switzerland) · 2023Review
- Disease state associated with chronic toe lesions in hellbenders may alter anti-chytrid skin defenses.Scientific reports · 2023Article
- Peptides Isolated from Amphibian Skin Secretions with Emphasis on Antimicrobial Peptides.Toxins · 2022Review
- A Review of Non-Invasive Sampling in Wildlife Disease and Health Research: What's New?Animals : an open access journal from MDPI · 2022Review
- Inhibitory Bacterial Diversity and Mucosome Function Differentiate Susceptibility of Appalachian Salamanders to Chytrid Fungal Infection.Applied and environmental microbiology · 2022Article
- Early life skin microbial trajectory as a function of vertical and environmental transmission in Bornean foam-nesting frogs.Animal microbiome · 2021Article
- Article
- Peptides for Skin Protection and Healing in Amphibians.Molecules (Basel, Switzerland) · 2019Review
- Article
- Discovery of bioactive peptides as therapeutic agents for skin wound repair.Journal of tissue engineeringReview
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently emerged fungal diseases, Batrachochytrium dendrobatidis (Bd) and Batrachochytrium salamandrivorans (Bsal) are an increasing threat to amphibians worldwide. In Europe, the threat of Bsal to salamander populations is demonstrated by the rapid decline of fire salamander populations in Germany, the Netherlands and Belgium. Although most European urodelans are susceptible to infection in infection trials, recent evidence suggests marked interspecific differences in the course of infection, with potentially far reaching implications for salamander conservation. As a salamander's skin is the first line of defense against such pathogens, interspecific differences in innate immune function of the skin may explain differential susceptibility. Here we investigate if compounds present on a salamander's skin can kill Bsal spores and if there is variation among species. We used a non-invasive assay to compare killing ability of salamander mucosomes of four different species (captive and wild Salamandra salamandra and captive Ichtyosaura alpestris, Cynops pyrrhogaster and Lissotriton helveticus) by exposing Bsal zoospores to salamander mucosomes and determining spore survival. In all samples, zoospores were killed when exposed to mucosomes. Moreover, we saw a significant variation in this Bsal killing ability of mucosomes between different salamander host species. Our results indicate that mucosomes of salamanders might provide crucial skin protection against Bsal, and could explain why some species are more susceptible than others. This study represents a step towards better understanding host species variation in innate immune function and disease susceptibility in amphibians.
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