Evidence map›Paper›PMID 30020931›Full record

ArticlePLoS neglected tropical diseases2018

Peripheral nerve abnormality in HIV leprosy patients.

Marilia Brasil Xavier, Mariana Garcia Borges do Nascimento, Keila de Nazare Madureira Batista, Danusa Neves Somensi, Fernando Octavio Machado Juca Neto, Thomaz Xavier Carneiro, Claudia Maria Castro Gomes, Carlos Eduardo Pereira Corbett

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PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Marilia Brasil XavierNucleo de Medicina Tropical, Universidade Federal do Para, Belem, Para, Brazil.ORCID 0000-0002-4727-3001
Mariana Garcia Borges do NascimentoNucleo de Medicina Tropical, Universidade Federal do Para, Belem, Para, Brazil.
Keila de Nazare Madureira BatistaFaculdade de Fisioterapia, Universidade Federal do Para, Belem, Para, Brazil.
Danusa Neves SomensiCentro de Ciencias Biologicas e da Saude, Universidade do Estado do Para, Belem, Para, Brazil.
Fernando Octavio Machado Juca NetoCentro de Ciencias Biologicas e da Saude, Universidade do Estado do Para, Belem, Para, Brazil.
Thomaz Xavier CarneiroNucleo de Medicina Tropical, Universidade Federal do Para, Belem, Para, Brazil.
Claudia Maria Castro GomesFaculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil.
Carlos Eduardo Pereira CorbettFaculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil.
Universidade do Estado do Pará · BRUniversidade Federal do Pará · BRHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe geographical overlap of HIV (human immunodeficiency virus) and leprosy infection has become increasingly frequent and worrying, bringing many clinical issues. Peripheral neuropathy is very frequent in leprosy because of the predilection of its etiologic agent by Schwann cells of the peripheral nervous system, and it also affects individuals with HIV as one of the most common neurological manifestations. METHODOLOGY/PRINCIPAL

findingsThe present study compared a cohort of 63 patients diagnosed with leprosy and coinfected with HIV with a cohort of 64 patients with leprosy alone, who were followed at the outpatient clinic of the Nucleus of Tropical Medicine of the Federal University of Pará, Brazil. We observed that HIV-coinfected leprosy patients presented greater odds of overall peripheral nerve damage (nerve function impairment-NFI) than patients with leprosy alone. More sensitive damage was observed, especially in patients coinfected with multibacillary forms. Leprosy patients coinfected with HIV presented higher chances of motor damage with improvement over time using multidrug therapy (MDT) and highly active antiretroviral therapy (HAART), along with a greater extent of damage and occurrence of neuritis. The data suggest that in addition to patients presenting possible damage caused by leprosy, they also had a greater damage gradient attributable to HIV disease, but not related to HAART because most of these patients had been on the treatment for less than a year. Neuritis was treated with prednisone at doses recommended by the WHO, and coinfected patients had the highest rate of clinical improvement in the first 60 days. CONCLUSIONS/SIGNIFICANCE: The clinical characteristics of the two diseases should be considered in leprosy patients coinfected with HIV for better diagnosis and treatment of peripheral neuropathy. We suggest that new simplified assessment tools that allow the evaluation of the NFI of these patients be developed for use in the service.

Indexed as

AdolescentAdultAgedAnti-HIV AgentsBrazilCohort StudiesCoinfectionFemaleHIV InfectionsHumansLeprostatic AgentsLeprosyMaleMiddle AgedPeripheral NervesPeripheral Nervous System DiseasesAnti-HIV AgentsLeprostatic Agents

Identifiers

PMID30020931
PMCPMC6066254
OpenAlexW2883709776

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.