Evidence map›Paper›PMID 30019993›Full record

Trial reportJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2018

Safety, feasibility, and potential efficacy of intraarterial selective cooling infusion for stroke patients treated with mechanical thrombectomy.

Chuanjie Wu, Wenbo Zhao, Hong An, Longfei Wu, Jian Chen, Mohammed Hussain, Yuchuan Ding, Chuanhui Li, Wenjing Wei, Jiangang Duan and 5 more

2 registry-linked trialsOpen access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 77 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 5 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05676957 naunknown statusnot on this mapstarted 2023, after this paper: background citation

A Prospective, Randomized-controlled Trial to Assess the Safety and Efficacy of Intravascular Hypothermia in Acute Ischemia Stroke Patients With Recanalization After Thrombectomy

TypeinterventionalSponsorLiping LiuRan2023 to 2024Enrolled30ConditionsIschemic Stroke, Revascularization, Endovascular Treatment, Reperfusion InjuryArmsThermogard XP3
NCT06634303 nacompletednot on this mapstarted 2025, after this paper: background citation

Hybernia Delta H (ΔH) Brain Cooling System for: Post-Mechanical Endovascular Cerebral Cooling

TypeinterventionalSponsorHybernia MedicalRan2025 to 2026Enrolled8ConditionsAcute Ischemic StrokeArmsBrain cooling
3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 5 syntheses or guidelines pooled it, 111 citations in OpenAlex.

  1. Pooled it
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  9. Arterial Glyceryl Trinitrate in Acute Ischemic Stroke After Thrombectomy for Neuroprotection (AGAIN): A Pilot Randomized Controlled Trial.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Trial
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  15. Target temperature management in acute ischemic stroke.Frontiers in molecular biosciences · 2026
    Review
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Chuanjie Wu1 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Wenbo Zhao1 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Hong An1 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Longfei Wu1 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Jian Chen2 Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Mohammed Hussain3 Department of Neurointerventional Surgery, Hartford Hospital, Hartford, CT, USA.
Yuchuan Ding4 Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI, USA.
Chuanhui Li2 Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Wenjing Wei1 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Jiangang Duan5 Department of Emergency, Xuanwu Hospital, Capital Medical University, Beijing, China.
Chunmei Wang6 Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Qi Yang7 Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Di Wu8 China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China.
Liqiang Liu1 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Xunming Ji2 Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Capital Medical University · CNHartford Hospital · USWayne State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This is a prospective non-randomized cohort study of 113 consecutive patients to investigate the safety and efficacy of a short-duration intraarterial selective cooling infusion (IA-SCI) targeted into an ischemic territory combined with mechanical thrombectomy (MT) in patients with large vessel occlusion-induced acute ischemic stroke (AIS); 45/113 patients underwent IA-SCI with 350 ml 0.9% saline at 4℃ for 15 min at the discretion of the interventionalist. Key parameters such as vital signs and key laboratory values, symptomatic and any intracranial hemorrhage, coagulation abnormalities, pneumonia, urinary tract infections and mortality were not significantly different between the two groups. Final infarct volume (FIV) was assessed on noncontrast CT performed at three to seven days. After an adjusted regression analysis, the between-group difference in FIV (19.1 ml; 95% confidence interval (CI) 3.2 to 25.2; P = 0.038) significantly favored the IA-SCI group. At 90 days, no differences were found in the proportion of patients who achieved functional independence (mRS 0-2) (51.1% versus. 41.2%, adjusted odd ratio (aOR) 1.9, 95% CI 0.8-2.6, P = 0.192). Combining short-duration IA-SCI with MT was safe. There was a smaller FIV and trend towards clinical benefit that will need to be further evaluated in randomized control trials.

Indexed as

Mechanical ThrombolysisAgedCohort StudiesFeasibility StudiesFemaleHumansHypothermia, InducedInfusions, Intra-ArterialMaleMiddle AgedProspective StudiesStrokeThrombectomyendovascular proceduresHypothermiaintra-arterial infusionsneuroprotectionreperfusion injury

Identifiers

PMID30019993
PMCPMC6282221
OpenAlexW2884469766

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.