ArticleAmerican journal of physiology. Renal physiology2018
The murine dialysis fistula model exhibits a senescence phenotype: pathobiological mechanisms and therapeutic potential.
Article in American journal of physiology. Renal physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD): A Pilot Clinical Trial.The journal of prevention of Alzheimer's disease · 2022Trial
- Senolytic Changes in Murine Arteriovenous Fistulas with CKD.Kidney360 · 2026Article
- Cellular and molecular mechanisms underlying hemodialysis arteriovenous fistula dysfunction and approaches to promote maturation: a vascular perspective.American journal of physiology. Heart and circulatory physiology · 2025Review
- Targeting senescent cells for the treatment of age-associated diseases.Journal of biochemistry · 2025Review
- Senescent Cells: An Emerging Therapeutic Target for Hemodialysis Fistula Maturation.Kidney360 · 2025Article
- Potential Clinical Implications of Senotherapies for Cardiovascular Disease.Circulation journal : official journal of the Japanese Circulation Society · 2024Article
- The potential for senotherapy as a novel approach to extend life quality in veterinary medicine.Frontiers in veterinary science · 2024Review
- Bioinformatics identifies predictors of arteriovenous fistula maturation.The journal of vascular access · 2024Article
- Impact of Geroscience on Therapeutic Strategies for Older Adults With Cardiovascular Disease: JACC Scientific Statement.Journal of the American College of Cardiology · 2023Review
- Review
- Translating the Biology of Aging into New Therapeutics for Alzheimer's Disease: Senolytics.The journal of prevention of Alzheimer's disease · 2023Review
- Cellular senescence and senolytics: the path to the clinic.Nature medicine · 2022Review
- A Murine Model of Hemodialysis Access-related Hand Dysfunction.Journal of visualized experiments : JoVE · 2022Article
- Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans.EBioMedicine · 2022Article
- Mechanisms of vascular dysfunction in the interleukin-10-deficient murine model of preeclampsia indicate nitric oxide dysregulation.Kidney international · 2021Article
- Review
- Development of a murine iliac arteriovenous fistula model for examination of hemodialysis access-related limb pathophysiology.JVS-vascular science · 2021Article
- Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Senolytic drugs: from discovery to translation.Journal of internal medicine · 2020Review
- Reducing Senescent Cell Burden in Aging and Disease.Trends in molecular medicine · 2020Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
There is no therapy that promotes maturation and functionality of a dialysis arteriovenous fistula (AVF). The search for such therapies largely relies on evaluation of vascular responses and putative therapies in experimental AVFs. We studied an AVF in mice with chronic kidney disease (CKD). We demonstrate numerous stressors in the vein of the AVF-CKD group, including pathological shear, mitogenic, inflammatory, and hypoxia-reoxygenation stress. Because stress promotes premature senescence, we examined whether senescence is induced in the vein of the AVF-CKD model. We demonstrate a senescence phenotype in the AVF-CKD model, as indicated by increased expression of p16
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.