Evidence map›Paper›PMID 30019672›Full record

ArticleeLife2018

Regenerating hair cells in vestibular sensory epithelia from humans.

Ruth Rebecca Taylor, Anastasia Filia, Ursula Paredes, Yukako Asai, Jeffrey R Holt, Michael Lovett, Andrew Forge

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
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  9. Article
  10. Article
  11. Article
  12. Article
  13. Modern In Vitro Techniques for Modeling Hearing Loss.Bioengineering (Basel, Switzerland) · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. AAV-ie-K558R mediated cochlear gene therapy and hair cell regeneration.Signal transduction and targeted therapy · 2022
    Article
  20. Regeneration of Hair Cells in the Human Vestibular System.Frontiers in molecular neuroscience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ruth Rebecca TaylorUCL Ear Institute, University College London, London, United Kingdom.ORCID https://orcid.org/0000-0001-7359-1604
Anastasia FiliaNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Ursula ParedesUCL Ear Institute, University College London, London, United Kingdom.
Yukako AsaiF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, United States.
Jeffrey R HoltF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, United States.
Michael LovettNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Andrew ForgeUCL Ear Institute, University College London, London, United Kingdom.ORCID http://orcid.org/0000-0002-0995-0219
University College London · GBBoston Children's Hospital · USImperial College London · GB

Funding

Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SAHIN, MUSTAFA · 2016 to 2020
$5.2M
Dunhill Medical Trust Project grant R395/1114Dunhill Medical Trust R395/1114Medical Research Council G1000068Medical Research Council Project grant,G1000068NICHD NIH HHS U54 HD090255
6 · The paper itself

Abstract

Human vestibular sensory epithelia in explant culture were incubated in gentamicin to ablate hair cells. Subsequent transduction of supporting cells with

Indexed as

AdenoviridaeBasic Helix-Loop-Helix ProteinsEpitheliumGene Expression RegulationGentamicinsGreen Fluorescent ProteinsHair Cells, VestibularHumansMyosinsMyosin VIIaReceptors, NotchRegenerationSaccule and UtricleSignal TransductionTransduction, GeneticATOH1 protein, humanBasic Helix-Loop-Helix ProteinsGentamicinsGreen Fluorescent ProteinsMYO7A protein, humanMyosinsMyosin VIIaReceptors, Notchhair cellshumanhuman biologymedicineneuroscienceregenerationtranscriptomicsvestibular

Identifiers

PMID30019672
PMCPMC6078492
OpenAlexW2884766179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.