Trial reportPediatric obesity2019
Increased brain and behavioural susceptibility to portion size in children with loss of control eating.
Trial report in Pediatric obesity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The cerebellum plays more than one role in the dysregulation of appetite: Review of structural evidence from typical and eating disorder populations.Brain and behavior · 2023Pooled it
- Children's Portion Selection Is Predicted by Food Liking and Is Related to Intake in Response to Increased Portions.The Journal of nutrition · 2022Trial
- Altered hypothalamic functional connectivity in adolescents with severe obesity.International journal of obesity (2005) · 2026Observational
- Altered Hypothalamic functional connectivity in adolescents with severe obesity.Research square · 2026Article
- Empirical validation of a developmental model for binge-eating disorder in adolescents: a structural equation modeling approach.Journal of eating disorders · 2025Article
- Cortical thickness and childhood eating behaviors: differences according to sex and age, and relevance for eating disorders.Eating and weight disorders : EWD · 2024Article
- PACE: a Novel Eating Behavior Phenotype to Assess Risk for Obesity in Middle Childhood.The Journal of nutrition · 2024Article
- Does 'portion size' matter? Brain responses to food and non-food cues presented in varying amounts.Appetite · 2024Article
- The Cerebellar Response to Visual Portion Size Cues Is Associated with the Portion Size Effect in Children.Nutrients · 2024Article
- Neural correlates of appetite in adolescents.Appetite · 2023Article
- Children with lower ratings of executive functions have a greater response to the portion size effect.Appetite · 2023Article
- Loss of control eating in children is associated with altered cortical and subcortical brain structure.Frontiers in psychology · 2023Article
- Heterogeneity in PFC-amygdala connectivity in middle childhood, and concurrent interrelations with inhibitory control and anxiety symptoms.Neuropsychologia · 2022Article
- Article
- Assessment of loss-of-control eating in healthy youth by interview and questionnaire.The International journal of eating disorders · 2020Article
- Loss-of-Control Eating and Obesity Among Children and Adolescents.Current obesity reports · 2019Review
- A developmental framework of binge-eating disorder based on pediatric loss of control eating.The American psychologistArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundPortion size influences intake (i.e. the portion size effect [PSE]), yet determinants of susceptibility to the PSE are unclear.
objectiveWe tested whether children who reported an episode of loss of control (LOC) eating over the last 3 months would be more susceptible to the PSE and would show differential brain responses to food cues compared with children with no-LOC.
methodsAcross five sessions, children (n = 47; 7-10 years) consumed four test meals at 100%, 133%, 167% and 200% conditions for portion size and completed a functional magnetic resonance imaging scan while viewing pictures of foods varied by portion size and energy density (ED). Incidence of LOC over the past 3 months was self-reported. Random coefficient models were tested for differences in the shape of the PSE curve by LOC status. A whole-brain analysis was conducted to determine response to food cues during the functional magnetic resonance imaging.
resultsReported LOC (n = 13) compared with no-LOC (n = 34) was associated with increased susceptibility to the PSE, as evidenced by a positive association with the linear slope (P < 0.005), and negative association with the quadratic slope (P < 0.05) of the intake curve. Children who reported LOC compared with no-LOC showed increased activation in the left cerebellum to small relative to large portions (P < 0.01) and right cerebellum to High-ED relative to Low-ED food cues (P < 0.01).
conclusionChildren who reported LOC were more susceptible to the PSE and showed alterations in food-cue processing in the cerebellum, a hindbrain region implicated in satiety signalling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.