ArticleDiabetes, obesity & metabolism2018
Dissection of hepatic versus extra-hepatic insulin clearance: Ethnic differences in childhood.
Article in Diabetes, obesity & metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- A Systematic Review of Beta Cell Function in Adults of Black African Ethnicity.Journal of diabetes research · 2019Pooled it
- Influence of adiposity, insulin resistance, and intrahepatic triglyceride content on insulin kinetics.The Journal of clinical investigation · 2020Trial
- Insulin Hypersecretion and Increased Ectopic Fat in South Asian American Adolescents and Young Adults Compared With White and African American Peers: The CHARISMA Study.Diabetes care · 2026Article
- Sex-Specific Differences in Post-Load Insulin Dynamics Are Independent of BMI-Based Adiposity and BIA-Derived Body Composition and Pubertal Stage in Adolescents with Obesity.Journal of clinical medicine · 2026Article
- Distinct metabolic phenotypes in adolescents with obesity identified by unsupervised learning: associations with insulin resistance and resting energy expenditure.Frontiers in endocrinology · 2026Article
- Metabolic clearance rate of insulin across the glucose tolerance spectrum by race and ethnicity in youth with obesity.Obesity (Silver Spring, Md.) · 2025Article
- Insulin Sensitivity and Skeletal Muscle Mitochondrial Respiration in Black and White Women With Obesity.The Journal of clinical endocrinology and metabolism · 2025Article
- Equitable Management of Type 2 Diabetes in American Indian and Alaska Native Adults.Clinical diabetes : a publication of the American Diabetes Association · 2025Article
- Socioeconomic and ethnic inequalities increase the risk of type 2 diabetes: an analysis of NHS health check attendees in Birmingham.Frontiers in public health · 2024Article
- Sleeve Gastrectomy-Induced Weight Loss Increases Insulin Clearance in Obese Mice.International journal of molecular sciences · 2023Article
- The Physiology of Insulin Clearance.International journal of molecular sciences · 2022Review
- β-cell function in black South African women: exploratory associations with insulin clearance, visceral and ectopic fat.Endocrine connections · 2021Article
- Response to Comment on Piccinini and Bergman The Measurement of Insulin Clearance. Diabetes Care 2020;43:2296-2302.Diabetes care · 2021Article
- The Measurement of Insulin Clearance.Diabetes care · 2020Review
- Race affects the association of obesity measures with insulin sensitivity.The American journal of clinical nutrition · 2020Article
- Origins and History of the Minimal Model of Glucose Regulation.Frontiers in endocrinology · 2020Article
- Novel aspects of the role of the liver in carbohydrate metabolism.Metabolism: clinical and experimental · 2019Review
- Hypothesis: Role of Reduced Hepatic Insulin Clearance in the Pathogenesis of Type 2 Diabetes.Diabetes · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
aimsAdult African American (AA) women have one third of the hepatic insulin clearance of European American (EA) women. This lower hepatic (but not extra-hepatic) insulin clearance in AA individuals is associated with higher plasma insulin concentrations. This study aims to understand whether impairment of hepatic insulin clearance is seen in AA individuals since childhood, possibly suggesting that genetic/epigenetic factors, rather than lifestyle only, contribute to this. MATERIALS AND
methodsA total of 203 children (105 male and 98 female (55 AA, 88 EA and 60 Hispanic American [HA]; ages, 7-13 years; mean BMI, 19 kg/m
resultsFractional hepatic insulin extraction (FE
conclusionsAt a young age, FE
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.