Evidence map›Paper›PMID 30019335›Full record

ArticleThe Journal of physiology2018

GABA beyond the synapse: defining the subtype-specific pharmacodynamics of non-synaptic GABA

Andre H Lagrange, NingNing Hu, Robert L Macdonald

Abstract read
In one paragraph

Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. A therapeutic small molecule enhances γ-oscillations and improves cognition/memory in Alzheimer's disease model mice.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  2. Region and layer-specific expression of GABAFrontiers in cellular neuroscience · 2024
    Article
  3. Article
  4. Review
  5. Advances in the Electrophysiological Recordings of Long-Term Potentiation.International journal of molecular sciences · 2023
    Review
  6. Article
  7. Virally-induced expression of GABAProgress in neurobiology · 2022
    Article
  8. Article
  9. Endogenous ion channels expressed in human embryonic kidney (HEK-293) cells.Pflugers Archiv : European journal of physiology · 2022
    Review
  10. Article
  11. Review
  12. Review
  13. δ subunit-containing GABAThe Journal of physiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andre H LagrangeDepartments of Neurology, Vanderbilt University Medical Center, Nashville, TN, 37240-7915, USA.ORCID 0000-0003-0147-7778
NingNing HuDepartments of Neurology, Vanderbilt University Medical Center, Nashville, TN, 37240-7915, USA.
Robert L MacdonaldDepartments of Neurology, Vanderbilt University Medical Center, Nashville, TN, 37240-7915, USA.ORCID 0000-0002-9539-5556

Funding

RECOMBINANT/NATIVE GABAA RECEPTORSR01NS033300 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MACDONALD, ROBERT LOUDEN · 1995 to 2016
$5.0M
Effects of prolonged seizures on GABAA receptor functionK08NS045122 · NINDS · VANDERBILT UNIVERSITY · PI LAGRANGE, ANDRE H · 2004 to 2008
$820k
BLRD VA I01 BX001189NINDS NIH HHS K08 NS045122NINDS NIH HHS NS33300NINDS NIH HHS R01 NS033300
6 · The paper itself

Abstract

key pointsPhysiologically relevant combinations of recombinant GABA ABSTRACT: GABA

Indexed as

Action PotentialsAnimalsGABA Agentsgamma-Aminobutyric AcidHEK293 CellsHumansProtein IsoformsRatsReceptors, GABA-AGABA Agentsgamma-Aminobutyric AcidProtein IsoformsReceptors, GABA-Aelectrophysiologymolecular pharmacologyTonic Inhibition

Identifiers

PMID30019335
PMCPMC6138284

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.