ArticleExperimental brain research2018
Balance in multiple sclerosis: relationship to central brain regions.
Article in Experimental brain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Effectiveness of vestibular rehabilitation in patients with multiple sclerosis: a systematic review and meta-analysis of randomized controlled trials.Journal of neurology · 2026Pooled it
- Pooled it
- Brain Activity and Connectivity in Fatigued People with Multiple Sclerosis During a Static Balance Task: An fNIRS Study.Sensors (Basel, Switzerland) · 2026Article
- Article
- Review
- I-BaR: integrated balance rehabilitation framework.Frontiers in neurorobotics · 2024Article
- Mechanography in children: pediatric references in postural control.Journal of musculoskeletal & neuronal interactions · 2022Article
- The Larval Zebrafish Vestibular System Is a Promising Model to Understand the Role of Myelin in Neural Circuits.Frontiers in neuroscience · 2022Article
- Article
- Comprehensive Clinical Assessment of Vestibular Function in Multiple Sclerosis.Journal of neurologic physical therapy : JNPT · 2021Article
- Visual Dysfunction in Multiple Sclerosis and its Animal Model, Experimental Autoimmune Encephalomyelitis: a Review.Molecular neurobiology · 2021Review
- Article
- Visual Feedback and Postural Control in Multiple Sclerosis.Journal of clinical medicine · 2020Article
- Effectiveness of Vestibular Training for Balance and Dizziness Rehabilitation in People with Multiple Sclerosis: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2020Review
- Can optical flow perturbations detect walking balance impairment in people with multiple sclerosis?PloS one · 2020Article
- Increased ankle muscle coactivation in the early stages of multiple sclerosis.Multiple sclerosis journal - experimental, translational and clinicalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
Dizziness, postural instability, and ataxia are among the most debilitating symptoms of multiple sclerosis (MS), reflecting, in large part, dysfunctional integration of visual, somatosensory, and vestibular sensory cues. However, the role of MS-related supratentorial lesions in producing such symptoms is poorly understood. In this study, motor control test (MCT) and dynamic sensory organization test (SOT) scores of 58 MS patients were compared to those of 72 healthy controls; correlations were determined between the MS scores of 49 patients and lesion volumes within 26 brain regions. Depending upon platform excursion direction and magnitude, MCT latencies, which were longer in MS patients than controls (p < 0.0001), were correlated with lesion volumes in the cortex, medial frontal lobes, temporal lobes, and parietal opercula (r's ranging from 0.20 to 0.39). SOT test scores were also impacted by MS and correlated with lesions in these same brain regions as well as within the superior frontal lobe (r's ranging from - 0.28 to - 0.40). The strongest and most consistent correlations occurred for the most challenging tasks in which incongruent visual and proprioceptive feedback were given. This study demonstrates that supratentorial lesion volumes are associated with quantitative balance measures in MS, in accord with the concept that balance relies upon highly convergent and multimodal neural pathways involving the skin, muscles, joints, eyes, and vestibular system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.