Evidence map›Paper›PMID 30019183›Full record

ArticleSocial psychiatry and psychiatric epidemiology2018

The role of parent and offspring sex on risk for externalizing psychopathology in offspring with parental alcohol use disorder: a national Swedish study.

E C Long, S L Lönn, J Sundquist, K Sundquist, K S Kendler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Social psychiatry and psychiatric epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

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  8. Individual differences in the associations between risk factors for alcohol use disorder and alcohol use-related outcomes.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

E C LongVirginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Box 980126, Richmond, VA, 23298-0126, USA. longe@vcu.edu.
S L LönnCenter for Primary Health Care Research, Lund University, Malmö, Sweden.
J SundquistCenter for Primary Health Care Research, Lund University, Malmö, Sweden.
K SundquistCenter for Primary Health Care Research, Lund University, Malmö, Sweden.
K S KendlerVirginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics, Box 980126, Richmond, VA, 23298-0126, USA.
Lund University · SEVirginia Commonwealth University · USIcahn School of Medicine at Mount Sinai · US

Funding

Social, Developmental and Genetic Epidemiology of Alcohol Use DisordersR01AA023534 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI KENDLER, KENNETH SEEDMAN, SUNDQUIST, KRISTINA · 2015 to 2023
$4.0M
Genetics, Romantic Relationships, and Alcohol Misuse in Emerging AdulthoodK01AA024152 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI SALVATORE, JESSICA E · 2016 to 2020
$741k
National Institute on Alcohol Abuse and Alcoholism R01AA023534NIAAA NIH HHS K01 AA024152NIAAA NIH HHS R01 AA023534Swedish Research Council 2012-2378Swedish Research Council 2014-10134Swedish Research Council for Health, Working Life, and Welfare 2013-1836
6 · The paper itself

Abstract

purposeThe substantial literature showing that offspring of parents with alcohol use disorder (AUD) is at increased risk for externalizing psychopathology rarely examines the differential effects of parental and offspring sex. This literature also has other important limitations, such as modest sample sizes and use of unrepresentative samples. Using a large, nationwide Swedish sample, we aim to investigate the roles of parental and offspring sex in externalizing psychopathology among offspring with parental AUD.

methodsAUD diagnosis and externalizing measures were obtained from national registries. Associations between outcomes and parental AUD were examined using logistic regressions. Parental and offspring sex effects were examined with interaction terms.

resultsRisks for externalizing disorders were increased in sons and daughters with parental AUD, with significant differences between sons and daughters for criminal behavior; maternal AUD had a greater impact than paternal AUD (regardless of offspring sex), but having two parents with AUD increased risk for all outcomes substantially more than having one parent; and maternal AUD increased risk of drug abuse for daughters more than sons, while paternal AUD increased risk of AUD and criminal behavior for sons more than daughters.

conclusionsOffspring of parents with AUD are at increased risk for externalizing psychopathology. Maternal and paternal AUD differentially affected sons' vs. daughters' risks for AUD, drug abuse, and criminal behavior. The transmission of psychopathology within the externalizing spectrum appears to have sex-specific elements.

Indexed as

AlcoholismSex FactorsAdolescentAdultChildChild of Impaired ParentsCriminal BehaviorFemaleHumansMaleParentsPrevalencePsychopathologyRegistriesRisk FactorsSubstance-Related DisordersChildren of alcoholicsExternalizing disordersParental alcohol use disorderSex differences

Identifiers

PMID30019183
PMCPMC6252126
OpenAlexW2884338989

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.