Evidence map›Paper›PMID 30019172›Full record

ReviewClinical pharmacokinetics2018

Clinical Pharmacokinetics and Pharmacodynamics of Propofol.

Marko M Sahinovic, Michel M R F Struys, Anthony R Absalom

2 registry-linked trialsOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical pharmacokinetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 367 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
367citing papers in PubMed, 13 pooled it
45.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05701748 nacompletednot on this mapstarted 2023, after this paper: background citation

EEG to Monitor Propofol Anesthetic Depth in Infants and Toddlers

TypeinterventionalSponsorChildren's Hospital of PhiladelphiaRan2023 to 2025Enrolled100ConditionsElectroencephalography Spectral Edge Frequency, Anesthetic DepthArmsStimuli
NCT07456111 phase4recruitingnot on this mapstarted 2025, after this paper: background citation

A Comparison of Remimazolam Besylate and Propofol Sedation in Patients Undergoing Colonoscopic Polypectomy

TypeinterventionalSponsorClinical Hospital Centre ZagrebRan2025 to 2028Enrolled90ConditionsColonic Polyp, Sedation ComplicationArmsRemimazolam besylate, Propofol
3 · Its place in the literature

Who cites it

367 citing papers in PubMed, 13 syntheses or guidelines pooled it, 760 citations in OpenAlex.

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307 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Marko M SahinovicDepartment of Anaesthesiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands. M.sahinovic@umcg.nl.
Michel M R F StruysDepartment of Anaesthesiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
Anthony R AbsalomDepartment of Anaesthesiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
University of Groningen · NLGhent University · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Propofol is an intravenous hypnotic drug that is used for induction and maintenance of sedation and general anaesthesia. It exerts its effects through potentiation of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) at the GABA

Indexed as

AdultAnesthetics, IntravenousAnimalsChildDose-Response Relationship, DrugDrug InteractionsHumansHypnotics and SedativesModels, BiologicalObesityPropofolAnesthetics, IntravenousHypnotics and SedativesPropofol

Identifiers

PMID30019172
PMCPMC6267518
OpenAlexW2883595456

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.